Chronic wound healing is a complex process requiring sustained activity of growth factors across the whole healing process. Among these growth factors, platelet-derived growth factor (PDGF) plays a pivotal role. However, the short half-life of PDGF limits its therapeutic efficacy. This study introduces a hyaluronic acid-based hydrogel system loading with PDGF, MA-HA-Gel/PDGF, designed for the controlled release of PDGF. By tuning the ratio of cross-linkers with different hydrolysis rates, the PDGF loaded hydrogel system ensures sustained release of bioactive PDGF. In vivo assays proved that, MA-HA-Gel/PDGF could efficiently promote the proliferation and migration of fibroblasts. Furthermore, MA-HA-Gel/PDGF could enhance neovascularization and accelerate the wound closure of a chronic wound bearing mouse model. This PDFG loaded hydrogel system offers a promising strategy for chronic wound treatment.
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| http://dx.doi.org/10.1016/j.ijbiomac.2025.140710 | DOI Listing |
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