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Rethinking Neurodevelopmental Boundaries: Distinct and Overlapping Cortical Profiles in Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, and Their Comorbidity.
Biol Psychiatry
March 2025
Brain Imaging Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary. Electronic address:
Charting brain GABA and glutamate levels across psychiatric disorders by quantitative analysis of 121 H-MRS studies.
Psychol Med
November 2024
Laboratory of Cognitive Control and Brain Healthy, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, China.
Background: Psychiatric diagnosis is based on categorical diagnostic classification, yet similarities in genetics and clinical features across disorders suggest that these classifications share commonalities in neurobiology, particularly regarding neurotransmitters. Glutamate (Glu) and gamma-aminobutyric acid (GABA), the brain's primary excitatory and inhibitory neurotransmitters, play critical roles in brain function and physiological processes.
Methods: We examined the levels of Glu, combined glutamate and glutamine (Glx), and GABA across psychiatric disorders by pooling data from 121 H-MRS studies and further divided the sample based on Axis I disorders.
Cicchetti's organizational-developmental perspective of Down syndrome: Contributions to the emergence of developmental psychopathology and the study of persons with neurodevelopmental conditions.
Dev Psychopathol
December 2024
Department of Special Education, Vanderbilt University Peabody College, Nashville, TN, USA.
Dante Cicchetti's earliest work, his studies of social-emotional development in infants and children with Down syndrome, set the stage for the emergence of the larger field of developmental psychopathology. By applying basic developmental principles, methodologies, and questions to the study of persons with Down syndrome, Dante took on the challenge of searching for patterns in atypical development. In doing so, he extended traditional developmental theory and introduced a more "liberal" approach that both continues to guide developmentally based research with persons with neurodevelopmental conditions (NDCs), including Down syndrome.
View Article and Find Full Text PDFRethinking professional boundaries: the climate crisis and brain health.
BJPsych Bull
August 2024
St James's Hospital, Dublin, Ireland.
Since climate change affects psychiatric, neurological and neuropsychological disorders, as well as brain development, the Irish Doctors for the Environment working group on mental health has changed its title and remit to brain health. Mental health professionals need to respond coherently and effectively to the climate crisis. This need challenges traditional professional, disciplinary and academic boundaries and demands a holistic, person-centred approach.
View Article and Find Full Text PDFRethinking plasticity: Analysing the concept of "destructive plasticity" in the light of neuroscience definitions.
Eur J Neurosci
September 2024
Department of Philosophy, University Paris Nanterre, Nanterre Cedex, France.
As a multilevel and multidisciplinary field, neuroscience is designed to interact with various branches of natural and applied sciences as well as with humanities and philosophy. The continental tradition in philosophy, particularly over the past 20 years, tended to establish strong connections with biology and neuroscience findings. This cross fertilization can however be impeded by conceptual intricacies, such as those surrounding the concept of plasticity.
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