Objective: To compare the association between muscle strength (MS), cardiorespiratory fitness (CRF), and all-cause and cardiovascular disease (CVD) mortality.
Methods: The Copenhagen City Heart Study is a prospective longitudinal study comprising a random sample of adults; we excluded participants with a history of coronary heart disease or cancer, leaving 9896 men and women for analyses. A self-administered questionnaire at baseline (from October 10, 1991, to September 16, 1994) documented self-rated MS and CRF, categorized as low, moderate, or high. MS was measured in 3299 participants by a hand grip strength of the dominant hand with isometric dynamometry. Multivariable adjusted analyses were performed adjusting for potential confounders.
Results: During follow-up of 27 years, 4971 all-cause deaths and 2128 CVD deaths occurred. Compared with moderate CRF, high CRF was associated with lower all-cause mortality (hazard ratio, 0.82; 95% CI, 0.75 to 0.90) and lower CVD mortality (hazard ratio, 0.81; 95% CI, 0.70 to 0.93). There were approximately 10% higher risk reductions for CRF than for MS in comparing high with moderate levels for both all-cause and CVD mortality; comparing moderate with low levels, CRF was 19% (95% CI, -5% to 48%) better than MS for decreasing risk of all-cause mortality and 33% (95% CI, -6% to 89%) better for reducing CVD mortality. The self-rated MS reports corresponded well with the hand grip results.
Conclusion: Both CRF and MS are inversely associated with CVD mortality and all-cause mortality, but of the 2, CRF confers stronger protection.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.mayocp.2024.08.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing: a population-based study using human foetuses and the UK Biobank cohort.
EBioMedicine
February 2025
Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK; Institute for Clinical Research and Systems Medicine, Health and Medical University, Potsdam, Germany.
Background: Maternal smoking and foetal exposure to nicotine and other harmful chemicals in utero remains a serious public health issue with little knowledge about the underlying genetics and consequences of maternal smoking in ageing individuals. Here, we investigated the epidemiology and genomic architecture of maternal smoking in a middle-aged population and compare the results to effects observed in the developing foetus.
Methods: In the current project, we included 351,562 participants from the UK Biobank (UKB) and estimated exposure to maternal smoking status during pregnancy through self-reporting from the UKB participants about the mother's smoking status around their birth.
Efficacy of Acoramidis on All-Cause Mortality and Cardiovascular Hospitalization in Transthyretin Amyloid Cardiomyopathy.
J Am Coll Cardiol
March 2025
National Amyloidosis Centre, University College London, Royal Free Hospital, London, United Kingdom.
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed chronic disease associated with progressive heart failure that results in impaired quality of life, repeated hospitalizations, and premature death. Acoramidis is a selective, oral transthyretin stabilizer recently approved by the U.S.
View Article and Find Full Text PDFAssessing the link of malnutrition with diabetes and mortality risk in heart failure patients.
ESC Heart Fail
March 2025
Department of Musculoskeletal Ageing and Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
Aims: Malnutrition is increasingly recognized as a significant factor influencing the clinical outcomes of patients with heart failure (HF). Diabetes exacerbates risks like hospitalizations and mortality due to cardiovascular complications. The aim of this study was to explore the association of malnutrition with diabetes and its prognostic impact on all-cause and cardiovascular mortality in patients with HF, using the nutritional assessment tools, controlling nutritional status (CONUT) score and geriatric nutritional risk index (GNRI).
View Article and Find Full Text PDFSurgery in patients aged ≥ 80 years: mortality and recovery in a nationwide cohort study.
Anaesthesia
March 2025
Section of Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Introduction: As the global population ages, the demand for surgical interventions in older adults is rising. Older patients face increased risks due to age-related physiological changes and comorbidities, making surgery and postoperative care challenging. This study aimed to assess short- and long-term mortality, as well as patient-centred outcomes such as days alive and at home 30 and 90 days after surgery, in patients aged ≥ 80 y undergoing surgical procedures.
View Article and Find Full Text PDFAssessment of the prognostic performance of TIMI, PAMI, CADILLAC and GRACE scores for short-term major adverse cardiovascular events in patients undergoing emergent percutaneous revascularisation: a prospective observational study.
BMJ Open
March 2025
National Institute of Cardiovascular Diseases, Karachi, Pakistan.
Objectives: Accurately predicting short-term MACE (major adverse cardiac events) following primary percutaneous coronary intervention (PCI) remains a clinical challenge. This study aims to assess the effectiveness of four established risk scores in predicting short-term MACE after primary PCI.
Design: Prospective observational study.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!