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| http://dx.doi.org/10.1111/jocd.70014 | DOI Listing |
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Health risks of N,N -dimethylacetamide (DMAC) in humans.
J Occup Health
February 2025
Department of Preventive Medicine and Public Health, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
N,N-Dimethylacetamide (DMAC), which is widely used as an industrial solvent, can be absorbed via the respiratory tract and skin of humans exposed to DMAC. Hepatotoxicity is a main health risk of DMAC exposure in humans, and the relevant cases and epidemiological studies are reviewed herein. No hepatotoxicity was identified in workers exposed to approx.
View Article and Find Full Text PDFHealth risks of N,N -dimethylacetamide (DMAC) in humans.
J Occup Health
February 2025
Department of Preventive Medicine and Public Health, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
N,N-Dimethylacetamide (DMAC), which is widely used as an industrial solvent, can be absorbed via the respiratory tract and skin of humans exposed to DMAC. Hepatotoxicity is a main health risk of DMAC exposure in humans, and the relevant cases and epidemiological studies are reviewed herein. No hepatotoxicity was identified in workers exposed to approx.
View Article and Find Full Text PDFMicropore visualization and lifetime following microneedle application to skin of differing pigments.
Drug Deliv Transl Res
March 2025
Department of Pharmaceutical Sciences and Experimental Therapeutics, The University of Iowa College of Pharmacy, Iowa City, IA, 52242, USA.
Solid microneedles allow dermal delivery of drugs that cannot otherwise absorb through skin, via creation of epidermal micropores. The time that the micropores remain open (micropore lifetime) directly impacts drug delivery windows, and darker skin types have extended micropore lifetimes. Here we visualized dermal micropores and measured micropore lifetime in subjects with differing skin pigmentation (ClinicalTrials.
View Article and Find Full Text PDFTargeting uPARAP Modifies Lymphatic Vessel Architecture and Attenuates Lymphedema.
Circulation
March 2025
From the Laboratory of Tumor and Development Biology, GIGA, University of Liège, Sart-Tilman, Belgium. (F.G., A.L., S.P., F.B., E.I., S.B., J.D., L.B., A.P., C.M., M.G.-I., A.N.).
Background: Lymphedema is an incurable disease associated with lymphatic dysfunction that causes tissue swelling and fibrosis. We investigated whether lymphedema could be attenuated by interfering with uPARAP (urokinase plasminogen activator receptor-associated protein; gene), an endocytic receptor involved in fibrosis and lymphangiogenesis.
Methods: We generated mice with lymphatic endothelial cell (LEC)-specific deficiency and compared them with constitutive knockout mice by applying a preclinical model of secondary lymphedema (SL).
Clinical study on wound healing properties of Nile tilapia fish skin as biological dressing in dogs.
PLoS One
March 2025
Department of Small Animal and Clinical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Frequency of clinical cases of dogs with massive skin losses is very high in urban areas of Pakistan following road accidents, sharp objects exposure and attack by other dog. These cases need intensive veterinary assistance for safe and speedy healing of wounds. Recently, skin of Nile tilapia fish (Oreochromis niloticus) is internationally gaining hype in medical field as biological dressing to boost dermatological reconstruction process.
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