Mycosis fungoides (MF) is the most common subtype of primary cutaneous T-cell lymphoma characterized by malignant proliferation of T cells with epidermotropism in the skin. MF has an indolent course, presents as erythematous scaly patches or plaques, and may progress to generalized erythroderma, cutaneous tumors, or extracutaneous invasion. MF is often misdiagnosed at early stages due to nonspecific clinical findings. Patients with MF are at high risk for developing secondary malignancies, including hematological malignancies. We hereby report a case of MF misdiagnosed and associated with underlying diffuse large B-cell lymphoma.
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http://dx.doi.org/10.1002/ccr3.70172 | DOI Listing |
J Cutan Med Surg
March 2025
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Mycosis fungoides (MF) and Sézary syndrome (SS) are subtypes of cutaneous T-cell lymphoma with numerous topical and systemic therapies. Early-stage MF can be managed with topical corticosteroids, mechlorethamine, and phototherapy. However, patients are often non-responsive to topical therapies, thus requiring systemic therapies.
View Article and Find Full Text PDFAustralas J Dermatol
March 2025
Department of Dermatology, Ankara University Faculty of Medicine, Ankara, Turkey.
Background: Mycosis fungoides (MF) is the commonest form of primary cutaneous T-cell lymphoma. Progression is slow, with frequent relapses. Data for predicting early-stage MF progression and recurrence are inadequate.
View Article and Find Full Text PDFArch Dermatol Res
March 2025
Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Low-dose total skin electron beam therapy (TSEBT) is an effective treatment option for mycosis fungoides (MF) with proven palliative effects and reduced toxicity. Presented is an institutional analysis of survival/response rate and quality of life for MF patients with subgroup analysis of those possessing pathologic large cell transformation (LCT). This is a single institutional retrospective review of patients with mycosis fungicides treated from 2014 to 2023 with low-dose TSEBT.
View Article and Find Full Text PDFCurr Oncol Rep
March 2025
1st Department of Dermatology-Venereology, Medical School, National and Kapodistrian University of Athens, "Andreas Sygros" Hospital for Skin & Venereal Diseases, Athens, Greece.
Purpose Of Review: Cutaneous T-Cell Lymphoma (CTCL) poses challenges both in diagnosis and prognosis. The purpose of this review is to address the role of profiling immune and non-immune cells in the tumor microenvironment (TME) as it provides information for better diagnosis, prognosis, biomarker discovery, and personalized treatment strategies.
Recent Findings: Recent evidence suggests that the progression of CTCL is closely linked to the Tumor Microenvironment (TME) which comprises various cell types including immune cells, stromal cells, blood vessels, and the extracellular matrix.
Cancer Med
March 2025
Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Background: We investigated mental health diagnoses (MHDs) in mycosis fungoides (MF) patients compared to the general population, evaluated risk factors, and studied survival outcomes in a large population database.
Methods: MF patients from the Utah Cancer Registry diagnosed from 2001 to 2014 were matched with up to five general population individuals from the Utah Population Database. MHDs were retrospectively tracked in both populations (median follow-up = 6.
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