Africane-type sesquiterpenes are a growing family of natural products featuring a stereochemically complex 5/7/3 tricyclic skeleton, and their biosynthesis has not been well-investigated in fungi. Here, (1) an africanol () sesquiterpene cyclase was discovered by genome mining; (2) two cytochrome P450s were identified for conversion of compound to ophioceric acid () via formation of α,β-unsaturated ketone cyclopentane and a C14-carboxyl group; and (3) compound is a phytotoxin that inhibits root growth of .
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