Primary aldosteronism (PA) is rarely seen in pregnancy despite being a common cause of secondary hypertension. Spironolactone, the first-line treatment, is contraindicated in pregnancy due to potential anti-androgenic effects; treatment options are thus limited. We present a case in which severe hypokalaemia associated with PA was discovered during pregnancy. Eplerenone was used as a short-term treatment without adverse effects to the fetus before unilateral laparoscopic adrenalectomy was performed in the second trimester after the patient was refractory to medical treatment. This case report adds to the limited literature on management of PA in pregnancy, which could influence future risk-benefit discussions regarding surgical versus medical management of this condition.
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http://dx.doi.org/10.1136/bcr-2024-262767 | DOI Listing |
Clin Toxicol (Phila)
March 2025
Oregon Poison Center, Portland, OR, USA.
Introduction: "Snake" fireworks are a type of pyrotechnic device that, when ignited, burn and transform into a friable, snake-like structure. The inclusion of barium salts produces a green flame. Ingestion of these fireworks poses a risk of barium toxicity, which may result in hypokalemia, weakness, dysrhythmias, and respiratory distress.
View Article and Find Full Text PDFMed Trop Sante Int
December 2024
Service de neurologie, Centre hospitalier universitaire (CHU) de Cocody, Université Félix Houphouët Boigny, UFR des sciences médicales d'Abidjan, Cote d'Ivoire.
Introduction: Thyrotoxic hypokalemic periodic paralysis (THPP) is a sporadic form of hypokalemic periodic paralysis (HPP). It is a diagnostic and therapeutic emergency rarely described in the black population. We report a case in a black subject from Côte d'Ivoire.
View Article and Find Full Text PDFJ Clin Hypertens (Greenwich)
March 2025
Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
We conducted a retrospective cohort study to investigate changes in the aldosterone-to-renin ratio (ARR) and other influencing factors in patients with renal artery stenosis (RAS) and primary aldosteronism (PA). Patients with RAS and PA admitted to our hospital between January 2016 and December 2021 were retrospectively selected. Based on the standardized PA screening results, the patients were divided into aldosterone-to-renin ratio-positive and -negative groups.
View Article and Find Full Text PDFWorld J Clin Cases
March 2025
Department of Endocrinology and Metabolism, Zigong First People's Hospital, Zigong 643000, Sichuan Province, China.
Background: Thyrotoxic periodic paralysis (TPP) is an endocrine emergency caused by thyrotoxicosis, manifesting mainly as periodic myasthenia and hypokalemia, and posing a serious threat to the patient's health. Fatigue, strenuous exercise, alcohol abuse, high carbohydrate intake and insulin injections are common triggers of paralysis. This article reports a case of severe TPP induced by insulin injection, elucidates the characteristics and pathogenesis of the disease, analyses the risk factors for triggering TPP, and hopefully provides more clinical data for TPP patients.
View Article and Find Full Text PDFEur J Case Rep Intern Med
February 2025
Department of Internal Medicine, Staten Island University Hospital, New York City, USA.
Introduction: Hypokalemic periodic paralysis (HPP) presents a diagnostic challenge due to the painless muscle weakness it causes. This case discusses a patient with HPP along with electrocardiogram (ECG) findings of Brugada phenocopies (BrP) in the setting of hypokalemia. A review of the literature showed that it is the seventh documented example of BrP induced by hypokalemia alongside HPP.
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