[Annual progress of new drugs and new regimens for anti-tuberculosis treatment (2024)].

Zhonghua Jie He He Hu Xi Za Zhi

Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Research Institute, Beijing 101149, China.

Published: February 2025

China remains one of the countries with a high burden of tuberculosis (TB), with an estimated 748, 000 cases each year, ranking third in the world. The research and development of new drugs and new protocols plays a key role in the face of the requirements of the WHO's End TB Strategy. There are multiple new drugs in the clinical trial stage, such as macozinone, sutezoid, alpiberctin, and GSK3036656. The effectiveness, safety, and resistance issues of marketed drugs such as linezolid, bedaquiline, and delamanid are also of great concern. Meanwhile, short-term treatments for sensitive and drug-resistant TB have always been a hot topic in clinical research. WHO has also updated the preventive treatment plan for people at high risk of TB. This article reviews the literature published from October 1, 2023 to September 30, 2024.

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112147-20241016-00615DOI Listing

Publication Analysis

Top Keywords

[annual progress
4
drugs
4
progress drugs
4
drugs regimens
4
regimens anti-tuberculosis
4
anti-tuberculosis treatment
4
treatment 2024]
4
2024] china
4
china remains
4
remains countries
4

Similar Publications

Background: The adaptive immune system consists of T and B lymphocytes, with some B lymphocytes further differentiating into plasma cells that secrete antibodies and make up the humoral immune system. Extramedullary plasmacytoma, mucosa-associated lymphoid tissue (MALT) lymphoma, and plasmablastic lymphoma are all plasma cell-rich lymphoid neoplasms that rarely present in the female genital tract. To date, few case reports of these malignancies arising within the uterine cervix exist.

View Article and Find Full Text PDF

Introduction: The Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS), established nearly six decades ago, was initially designed as a specialized hospital for neurological care. However, over time, it has evolved into a multifaceted health institute, encompassing three fundamental pillars: clinical care, scientific research, and academic education in neurology.

Aims And Objectives: The purpose of this study is to strengthen and expand knowledge in the field of neurology.

View Article and Find Full Text PDF

Background: Globally, gastroenteritis stands as a primary contributor to child mortality, annually taking the lives of 3 million children under the age of 5 years. Rotavirus, a major factor in viral diarrhea among children aged 6 months to 2 years, presents with severe symptoms such as watery diarrhea and vomiting. Although mortality rates have decreased due to supportive care and vaccines, promising alternatives like N-acetylcysteine (NAC) show potential benefits in laboratory studies, indicating a possible supplementary strategy for managing rotavirus infections by reducing the duration and antigen excretion in feces.

View Article and Find Full Text PDF

We aimed at investigating the impact of coronavirus disease 2019 (COVID-19) on the time required to complete a 1000-m run and vital capacity (VC) among healthy male students at three universities in Wuhan, China, followed for four years covering the prepandemic (2019), early/late pandemic (2020/2021), and post-pandemic (2022) periods. Demographic information including age, body height/weight, and body mass index (BMI) were also collected. After dividing the participants into four groups based on BMI (i.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!