Surgical management of pontine brainstem cavernous malformations: A systematic review Emphasizing safe entry zones and clinical outcomes.

Objective: Safe entry zones (SEZs) have emerged as important corridors for accessing brainstem cavernous malformations (BSCM) while minimizing morbidity. This systematic review and meta-analysis aims to provide a comprehensive analysis of the surgical management of pontine BSCM via SEZs.

Methods: A systematic literature search was performed in PubMed for articles reporting on the surgical management of pontine BSCM via SEZ. Data were extracted on patient demographics, clinical presentation, BSCM characteristics, surgical approach, use of SEZs, and clinical outcomes.

Results: Fifteen studies with a total of 78 patients were included. The cohort was 62.8 % female with an average age of 37.62 ± 14.7 years. The most common presenting symptoms varied based on BSCM location within the pons. The two most common BSCM locations were peritrigeminal (24.4 %) and middle peduncle (10.3 %). The most frequently used surgical approach was the retrosigmoid approach (41.0 %), and the most commonly utilized SEZ was the lateral pontine zone (52.2 %). Gross total resection was achieved in 69.2 % of cases. Good clinical outcome (follow-up mRS < 2) was observed in 64.1 % of patients, with clinical deterioration observed in 7.7 %.

Conclusion: Surgical resection of pontine BSCM can be performed with acceptable morbidity and mortality rates when utilizing SEZs and careful preoperative planning. The lateral pontine, supratrigeminal, and peritrigeminal SEZs are associated with high rates of complete resection and improved neurological outcomes. Future studies with standardized reporting and longer follow-ups are needed to further refine surgical techniques and patient selection.