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The research progress of biologics in elderly-onset rheumatoid arthritis (EORA).
Front Aging
January 2025
Department of Rheumatology, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, China.
is a distinct subtype of characterized by heightened treatment challenges due to immune aging and the complexity of comorbidities. This review systematically summarizes the definition, clinical features, epidemiological trends, therapeutic challenges, and the potential applications of biologic agents in . It primarily focuses on the efficacy, safety, and individualized treatment strategies associated with various biologic agents.
View Article and Find Full Text PDFImmune-aging is linked to clinical malignancy, racial ancestry and vaccine responses in myeloma.
Blood Adv
February 2025
Emory University School of Medicine, Atlanta, Georgia, United States.
Cellular senescence-associated genes in rheumatoid arthritis: Identification and functional analysis.
PLoS One
January 2025
Department of Orthopaedics, The Fifth Hospital of Harbin, Harbin, Heilongjiang, P. R. China.
Rheumatoid arthritis (RA), a long-term autoinflammatory condition causing joint damage and deformities, involves a multifaceted pathogenesis with genetic, epigenetic, and immune factors, including early immune aging. However, its precise cause remains elusive. Cellular senescence, a hallmark of aging marked by a permanent halt in cell division due to damage and stress, is crucial in aging and related diseases.
View Article and Find Full Text PDFImmune Aging in Rheumatoid Arthritis.
Arthritis Rheumatol
January 2025
Mayo Clinic Alix School of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, and Stanford University School of Medicine, Stanford, California.
Rheumatoid arthritis (RA) is a life-long autoimmune disease caused by the confluence of genetic and environmental variables that lead to loss of self-tolerance and persistent joint inflammation. RA occurs at the highest incidence in individuals >65 years old, implicating the aging process in disease susceptibility. Transformative approaches in molecular immunology and in functional genomics have paved the way for pathway paradigms underlying the replacement of immune homeostasis with autodestructive immunity in affected patients, including the process of immune aging.
View Article and Find Full Text PDFChronological versus immunological aging: Immune rejuvenation to arrest cognitive decline.
Neuron
January 2025
Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel. Electronic address:
The contemporary understanding that the immune response significantly supports higher brain functions has emphasized the notion that the brain's condition is linked in a complex manner to the state of the immune system. It is therefore not surprising that immunity is a key factor in shaping brain aging. In this perspective article, we propose amending the Latin phrase "mens sana in corpore sano" ("a healthy mind in a healthy body") to "a healthy mind in a healthy immune system.
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