Cemento-osseous dysplasia (COD) is a non-neoplastic condition, characterized by the replacement of normal cancellous bone with fibrous tissues containing woven bone and cementum in the tooth-bearing areas. This report presents the case of a 21-year-old male who developed COD following orthodontic treatment. A panoramic radiograph showed a periapical radiolucent lesion in the right mandibular canine area. Cone beam computed tomography revealed a mixed radiolucent and radiopaque lesion. Histologically, the lesion exhibited cementum-like calcifications and woven bone scattered within the hemorrhagic fibrous tissue. Ultimately, the lesion was diagnosed as cemento-osseous dysplasia, focal type. This case highlights the importance of careful monitoring of orthodontic forces to minimize risks and prevent unexpected complications during orthodontic treatment.
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http://dx.doi.org/10.1097/SCS.0000000000011128 | DOI Listing |
Head Neck Pathol
February 2025
Research Institute and Museum of Anthropology, Lomonosov Moscow State University, Moscow, 125009, Russia.
Purpose: The earliest known case of cemento-osseous dysplasia could be detected in a Bronze Age skeleton, dating back 4500 years ago in the region of the North Caucasus. Although the soft tissue was missing, sufficient diagnosis could be achieved by using different methods that prove the existence of fibro-osseous processes already in prehistory. Skeletal remains provide a direct view of such changes which cannot be obtained from a living patient without compromising.
View Article and Find Full Text PDFJ Craniofac Surg
February 2025
Department of Oral and Maxillofacial Radiology and Wonkwang Dental Research Institute, College of Dentistry, Wonkwang University, Iksan.
Cemento-osseous dysplasia (COD) is a non-neoplastic condition, characterized by the replacement of normal cancellous bone with fibrous tissues containing woven bone and cementum in the tooth-bearing areas. This report presents the case of a 21-year-old male who developed COD following orthodontic treatment. A panoramic radiograph showed a periapical radiolucent lesion in the right mandibular canine area.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Mackay Memorial Hospital, Taipei, Taiwan.
Background: Cemento-osseous dysplasia (COD) is the most common apical radiopaque lesion that develops in the tooth-bearing area. However, large, destructive lesions are rare. Herein, we report a case in which COD extended to bilateral condyles, affecting the entire mandible, and was managed with denosumab rather than surgical resection.
View Article and Find Full Text PDFFront Vet Sci
January 2025
Department of Anesthesiology and Surgery, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania.
Ossifying fibroma (OF) is a rare, benign fibro-osseous neoplasm that primarily originates from membranous bones. While most frequently documented in equines, OF has also been reported in other species, including dogs, though it remains uncommon. The condition poses significant diagnostic challenges due to its ambiguous presentation, often requiring differentiation from other benign and malignant intraosseous lesions.
View Article and Find Full Text PDFBone Rep
March 2025
Beijing Institute of Dental Research, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China.
Background: Gnathodiaphyseal dysplasia (GDD) is a rare autosomal dominant genetic disease characterized by osteosclerosis of the tubular bones and cemento-osseous lesions of the mandibles. () is the pathogenic gene, however, the specific molecular mechanism of GDD remains unclear. Herein, a knockin ( ) mouse model expressing the human mutation p.
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