We present measurements of the atmospheric depth of the shower maximum X_{max}, inferred for the first time on an event-by-event level using the surface detector of the Pierre Auger Observatory. Using deep learning, we were able to extend measurements of the X_{max} distributions up to energies of 100 EeV (10^{20} eV), not yet revealed by current measurements, providing new insights into the mass composition of cosmic rays at extreme energies. Gaining a 10-fold increase in statistics compared to the fluorescence detector data, we find evidence that the rate of change of the average X_{max} with the logarithm of energy features three breaks at 6.5±0.6(stat)±1(syst) EeV, 11±2(stat)±1(syst) EeV, and 31±5(stat)±3(syst) EeV, in the vicinity to the three prominent features (ankle, instep, suppression) of the cosmic-ray flux. The energy evolution of the mean and standard deviation of the measured X_{max} distributions indicates that the mass composition becomes increasingly heavier and purer, thus being incompatible with a large fraction of light nuclei between 50 and 100 EeV.
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http://dx.doi.org/10.1103/PhysRevLett.134.021001 | DOI Listing |
JAMA Cardiol
March 2025
Department of Cardiovascular Medicine and Section on Geriatrics and Gerontology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Importance: Excess body fat plays a pivotal role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). HU6 is a novel, controlled metabolic accelerator that enhances mitochondrial uncoupling resulting in increased metabolism and fat-specific weight loss.
Objective: To assess efficacy and safety of HU6 in reducing body weight, improving peak volume of oxygen consumption (VO2) and body composition among patients with obesity-related HFpEF.
JAMA Netw Open
March 2025
Exercise Medicine Research Institute, Edith Cowan University, Perth, Australia.
Importance: Sexual dysfunction is a common adverse effect of prostate cancer treatment, and current management strategies do not adequately address physical and psychological causes. Exercise is a potential therapy in the management of sexual dysfunction.
Objective: To investigate the effects of supervised, clinic-based, resistance and aerobic exercise with and without a brief psychosexual education and self-management intervention (PESM) on sexual function in men with prostate cancer compared with usual care.
Environ Sci Technol
March 2025
Analytical Chemistry Group, Department of Plant and Environmental Science, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark.
This study explores the correlation of contaminants of emerging concern (CECs) in wastewater effluents using liquid chromatography (LC), supercritical fluid chromatography (SFC), and comprehensive two-dimensional gas chromatography (GC × GC) with derivatization, all coupled to high-resolution mass spectrometry (HRMS). Over 300 compounds, including frequently overlooked highly polar and nonpharmaceutical CECs, were identified. Monitoring programs mainly focus on reducing variability and assessing pollution in wastewater treatment plant (WWTP) effluents under dry weather conditions, often neglecting wet-weather discharges.
View Article and Find Full Text PDFPhys Chem Chem Phys
March 2025
Technical University of Darmstadt, Electronic Structure of Materials, Darmstadt, Germany.
Defect chemistry is the classical approach to evaluate point-defect concentrations in solids depending on the chemical activity of the ( - 1) of constituents by evaluating the mass action laws of a number of defect reactions conserving species, lattice sites, and charge. In an alternative approach, formation energies of individual defects can be calculated to determine the dependence on the Fermi level and on the chemical potentials of the reservoirs. This contribution provides the quantitative relationship between the two approaches, offering the opportunity to compare calculated defect formation energies with experimentally determined quantities.
View Article and Find Full Text PDFProteomics
March 2025
Department of Clinical Biochemistry OE4340, Hannover Medical School, Hannover, Germany.
Protein N-glycosylation influences protein folding, stability, and trafficking, and has prominent functions in cell-cell adhesion and recognition. For the parasite Toxoplasma gondii, N-glycosylation of proteins is crucial for initial adhesion to host cells, parasite motility, and consequently, its ability to invade host cells. However, the glycoproteome of T.
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