Problem: Despite being at increased risk for severe COVID-19, pregnant women were initially excluded from vaccine clinical trials, which limited data regarding vaccine effectiveness and protection in this group. Aiming to better understand the immune response to vaccination during pregnancy, we compared the kinetics and titers of neutralizing and IgG antibodies generated against SARS-CoV-2 during vaccination with BNT162b2 (Pfizer-BioNTech) or CoronaVac (Sinovac Biotech) in a cohort of pregnant women.
Methods Of Study: We evaluated participants before vaccination and 30 days after each vaccine dose, using a multiplex bead assay to measure IgG antibodies against SARS-CoV-2 antigens (total spike, spike-1, spike-2, receptor binding domain, and nucleocapsid) and a live virus fluorescence reduction neutralization assay (FRNA) to quantify neutralizing antibodies.
Results: Our data showed that vaccination resulted in a robust humoral response, with a considerable increase in the levels of IgG and neutralizing antibodies after the first vaccine dose and a sustained neutralizing response after the vaccine boost. In addition, antispike IgG assays presented a slight decrease after the second dose, while the neutralization rate remained stable.
Conclusions: Immune response to the SARS-CoV-2 vaccine in pregnant women demonstrated an important increase in neutralizing antibodies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/aji.70053 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Global research trends and hotspots in mitochondria and asthma: A bibliometric and visualized analysis.
J Asthma
March 2025
Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Article Synopsis
- Asthma is a chronic respiratory disease involving inflammation and other respiratory issues, with mitochondria playing a crucial role in its underlying mechanisms.
- A bibliometric analysis of research from 2004 to mid-2024 identified 669 publications, showing significant growth in studies since 2015, primarily from the US, China, and the UK.
- Key themes include mitochondrial dysfunction and oxidative stress, with emerging research focusing on mitochondrial biogenesis and the NLRP3 inflammasome, suggesting opportunities for new therapeutic strategies targeting mitochondria in asthma treatment.
LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2.
Autophagy
March 2025
Department of Critical Care Medicine and Emergency, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cardiac dysfunction is a serious complication of sepsis-induced multiorgan failure in intensive care units and is characterized by an uncontrolled immune response to overwhelming infection. Type 2 innate lymphoid cells (ILC2s), as a part of the innate immune system, play a crucial role in the inflammatory process of heterogeneous cardiac disorders. However, the role of ILC2 in regulating sepsis-induced cardiac dysfunction and its underlying mechanism remain unknown.
View Article and Find Full Text PDFDefinitions, Diagnosis and Management of Postoperative Recurrence in Crohn's Disease Patients with Permanent Ileostomy - A Systematic Review and Meta-Analysis.
J Crohns Colitis
March 2025
Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Background And Aims: Over 10% of patients with Crohn's disease require permanent ileostomy. We aimed to summarize the existing data on diagnosis, definitions of recurrence, and management of Crohn's disease patients with permanent ileostomy.
Methods: MEDLINE, Embase, and CENTRAL databases were searched from inception to February 6, 2024.
The influence of genetic polymorphisms on cytokine profiles in pediatric COVID-19: a pilot study.
Front Pediatr
February 2025
International Research and Innovation in Medicine Program, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Introduction: Recent studies have underscored the importance of genetic factors in predicting COVID-19 susceptibility and severity. While cytokine storms are crucial in disease severity, genetic predisposition significantly influences immune responses. Our study examined genes related to SARS-CoV-2 invasion ) and interferon-induced immunity ().
View Article and Find Full Text PDFIdentification and functional characterization of T-cell exhaustion-associated lncRNA AL031775.1 in osteosarcoma: a novel therapeutic target.
Front Immunol
March 2025
Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Background: Osteosarcoma, an aggressive bone malignancy predominantly affecting children and adolescents, presents significant therapeutic challenges with a 5-year survival rate below 30% in metastatic cases. T-cell exhaustion, characterized by the overexpression of immune checkpoint molecules, contributes to osteosarcoma progression and immune evasion. Although targeting these inhibitory pathways has shown potential in restoring T-cell activity, the molecular regulators of T-cell depletion in osteosarcoma are poorly understood.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!