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Bioactivated scaffolds promote angiogenesis and lymphangiogenesis for dermal regeneration in vivo.
J Tissue Eng
March 2025
Division of Hand, Plastic and Aesthetic Surgery, LMU University Hospital, LMU Munich, Munich, Germany.
Chronic wounds represent an unresolved medical challenge with significant impact for patients' quality of life and global healthcare. Diverse in origin, ischemic-hypoxic and inflammatory conditions play central roles as pathological features that impede proper tissue regeneration. In this study, we propose an innovative approach to address this challenge.
View Article and Find Full Text PDFProgress in skin gene therapy: from the inside and out.
Mol Ther
March 2025
Department of Dermatology, Medical Faculty, Medical Center, University of Freiburg, Freiburg Germany 79106. Electronic address:
The skin is the largest organ of the body and forms and serves as the barrier for preventing external material from accessing and damaging internal organs. As the outward interface to the environment, it is accessible for the application of therapeutic agents and cellular and gene therapy represent attractive and promising options to treat severe genetic conditions for which palliation has long been the main stay. However, because of its barrier function, transit across and to the sub-dermal compartment can be challenging.
View Article and Find Full Text PDFProgerin mRNA Is Associated with Smoking and Signs of Increased Microvascular Damage in Patients with Diabetic Macular Edema.
Int J Mol Sci
February 2025
Department of Internal Medicine III, Cardiology and Angiology, Medical University Innsbruck, 6020 Innsbruck, Austria.
The premature aging disease Hutchinson-Gilford Syndrome (HGPS) is caused by defined mutations in the LMNA gene, resulting in the activation of a cryptic splice donor site, which leads to a defective truncated prelamin A protein called progerin. Notably, progerin expression has also been detected in non-mutated healthy individuals, and therefore, its involvement in the physiological aging process has been widely discussed. Since diabetes mellitus is associated with premature aging and increased cardiovascular mortality, we aimed to investigate the role of progerin expression in patients with diabetic retinopathy (DR).
View Article and Find Full Text PDFIn Vitro Evaluation and Clinical Effects of a Regenerative Complex with Non-Cross-Linked Hyaluronic Acid and a High-Molecular-Weight Polynucleotide for Periorbital Treatment.
Polymers (Basel)
February 2025
Regenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland.
Skin aging is a complex and multifactorial process influenced by both intrinsic and extrinsic factors. The periorbital area of the face is particularly susceptible to premature aging signs due to its delicate skin structure, and is a major concern for many individuals. While hyaluronic acid (HA)-based dermal filler products are commonly used for periorbital rejuvenation, novel approaches to effectively locally address the visible signs of aging are available.
View Article and Find Full Text PDF"Mosaic graft" technique and surgical dermal glue in Mohs micrographic surgery and general dermatologic surgery.
Dermatol Reports
February 2025
Centro Dermatologico Vdermastudio, Viareggio.
After Mohs micrographic surgery, derm surgeons utilize local flaps, full or partial thickness grafts, with good or acceptable cosmetic results. When we are dealing with older and problematic patients, blood thinner users, and non-collaborative people with large facial neoplasms, using flaps may be very difficult, and grafts become the best choice. Our aim was to assess a technique to graft very easily, quickly, and safely, full-thickness skin grafts in facial wounds, and have good cosmetic results in those older and problematic people.
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