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| http://dx.doi.org/10.1016/j.gendis.2024.101399 | DOI Listing |
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View Article and Find Full Text PDFCross-talk between lactate metabolism and immunity reveals CEP55 as a potential regulator in the immunosuppressive microenvironment of hepatocellular carcinoma.
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Bone is subjected to a plethora of mechanical stresses, which have been found to directly influence the equilibrium between bone resorption and formation. Taking this into account, we present herein a novel biomimicking 3-dimensional model that applies cyclic uniaxial compression onto cells co-cultured on 3-dimensionally printed scaffolds consisting of poly L-lactic acid/poly(ε-caprolactone)/poly(3-hydroxybutyrate--3-hydroxyvalerate)/Sr-nanohydroxyapatite. The aim is to investigate how compression can modulate the balance between osteogenesis and osteoclastogenesis in co-culture, as well as the polarization of macrophages.
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Article Synopsis
- Macrophages play a crucial role in the tumor microenvironment (TME) and communicate with tumor cells, significantly influencing tumor growth and development.
- The study focuses on exosomal lncRNAs, particularly SLC16A1-AS1 from hepatocellular carcinoma (HCC) exosomes, which drives the malignant progression by promoting M2 polarization of macrophages through a specific molecular mechanism.
- The interaction between SLC16A1-AS1 and M2 macrophages enhances HCC cell behaviors like proliferation and invasion, suggesting that targeting SLC16A1-AS1 could be a potential therapeutic strategy against HCC.
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