Previous research examining the ergogenic benefits of blackcurrant supplementation (BC) on exercise performance is contradictory. The BC supplementation period in many studies has typically been chronic (> 6-days), with a final dose taken hours before testing. Whether any observed performance benefits are from the acute dose or chronic supplementation is unclear. This study aimed to examine the effects on cycling performance of a single-acute dose and 7-day supplementation with BC extract. This study was a placebo-controlled, double-blind, randomised, cross-over trial. Sixteen cyclists (mean ± SD: age 37 ± 11 years; height 175.8 ± 7.6 cm; body mass 73.2 ± 12.5 kg; V̇O 3.8 ± 0.7 L·min) completed a total of six experimental sessions (2 × 3 treatment blocks). Each treatment block consisted of a no-supplement baseline trial, a single dose (acute) and a 7-day (chronic) supplementation trial. During each trial, subjects completed a maximal incremental test and 4 km time trial, separated by 15 min of recovery. Respiratory data, heart rate, muscle oxygenation and performance power were measured continuously in each trial, and differences between treatments were determined using RM-ANOVA and effect size analysis. There was no significant difference (p > 0.05) in cycling performance between experimental and placebo treatments following acute or chronic supplementation periods. There were no significant effects on measured physiological and metabolic parameters, and any observed differences in performance or physiology were trivial to small. Blackcurrant supplementation delivered either acutely or over a period of 7 days had no significant effect on cycling performance or physiology. TRIAL REGISTRATION: Australia New Zealand Clinical Trial Registry: ACTRN12622001277730.
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http://dx.doi.org/10.1002/ejsc.12267 | DOI Listing |
Ann Med
December 2025
Department of Assisted Reproductive Centre, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, China.
Background: Butyrate may inhibit SARS-CoV-2 replication and affect the development of COVID-19. However, there have been no systematic comprehensive analyses of the role of butyrate metabolism-related genes (BMRGs) in COVID-19.
Methods: We performed differential expression analysis of BMRGs in the brain, liver and pancreas of COVID-19 patients and controls in GSE157852 and GSE151803.
J Prosthet Dent
March 2025
Associate Professor, Department of Pedodontics, School of Dentistry, Ege University, Izmir, Turkey. Electronic address:
Statement Of Problem: Early childhood caries is one the world's most common problems in infants and treatment of posterior teeth with esthetic crowns in a low rate of wear on opposite dentition is a challenge for pediatric dentists.
Purpose: The purpose of this in vitro study was to evaluate the wear behavior of the tooth colored crown materials and the opposing teeth in using different esthetic crown materials in the mixed dentition period.
Material And Methods: The following tooth type and crown materials were considered in the experiment.
ACS Nano
March 2025
School of Environmental and Materials Engineering, Yantai University, Yantai 264005, China.
Zinc-ion batteries become a major research focus in energy storage, valued for their low cost and high safety. However, their widespread application is hindered by poor zinc anode stability caused by dendrites, side reactions, and poor performance across a wide temperature range at a strong hydrogen bond network aqueous electrolyte. In this study, we propose a strategy for the synergistic combination of a polyacrylamide hydrogel with sucrose.
View Article and Find Full Text PDFAnal Chim Acta
May 2025
College of Textile Science and Engineering, Jiangnan University, 1800Lihu Road, Wuxi, 214122, China. Electronic address:
Flexible sweat sensors possess the special potential for continuous non-invasive monitoring of human blood glucose. We put forward a flexible microcolumn array sensor, which is designed for health monitoring by means of detecting glucose levels in sweat and capturing physiological signals related to human movement. With the combination of silk fibroin (SF), waterborne polyurethane (PU), and multi-walled carbon nanotubes (MWCNT), this microcolumn film electrode is able to effectively function as a strain sensor benefiting from the superior mechanical performance of PU.
View Article and Find Full Text PDFAnal Chim Acta
May 2025
School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China. Electronic address:
Background: Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant with significant risks to ecosystems and human health. Magnetic molecularly imprinted polymers (MIPs) provide a promising solution for selectively extracting PFOS from contaminated water. However, while bifunctional monomer imprinting improves the imprinting effect by introducing diverse functional groups, it can also increase non-specific adsorption.
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