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Retina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Networks After Optic Nerve Crush in a Rat Model of Surgical Menopause.
Int J Mol Sci
February 2025
Center for Visual and Neurocognitive Rehabilitation, Joseph M. Cleland Atlanta VA Medical Center, Decatur, GA 30033, USA.
The association between 17β-estradiol (E2) deprivation, seen in menopause, and a risk for developing glaucoma has been shown. Thus, exogenous supplementation of E2 may protect against retinal ganglion cell (RGC) degradation and vision loss. Here, we investigated the utility of topical 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), a prodrug of E2 that selectively produces the neuroprotective hormone in the retina, on visual function after optic nerve crush (ONC) and ovariectomy (OVX).
View Article and Find Full Text PDFComputed tomography accuracy and features in detecting open globe injuries in patients with ocular trauma: a systematic review and meta-analysis.
J Med Life
January 2025
Radiology Department, King Fahad Hospital, Madinah, Saudi Arabia.
Open globe injuries (OGIs) can have devastating impacts on patients' lives. Early detection of OGIs is crucial for improving outcomes, as any delay in treatment can result in significant consequences. Radiological imaging, particularly computed tomography (CT), aids ophthalmologists in diagnosing this condition, especially in challenging cases.
View Article and Find Full Text PDFManagement of corneal injuries in spaceflight and recommendations for planetary missions.
NPJ Microgravity
March 2025
Center for Space Medicine, Baylor College of Medicine, Houston, Texas, USA.
In February 1968, NASA purchased 400 antigravity ballpoint pens from the Fisher Pen Company for the Apollo Program to prevent potential harm to astronauts and equipment. Mechanical pencils previously used in microgravity posed risks like eye injuries from floating fragments penetrating the cornea. The cornea is vulnerable to abrasions, perforations, and chemical burns in such environments, affecting crewmembers aboard the International Space Station (ISS).
View Article and Find Full Text PDFDemographic analysis of patients requiring ophthalmology consultation in the emergency department: A retrospective study at a tertiary care center.
Medicine (Baltimore)
March 2025
Department of Family Medicine, University of Health Sciences Turkey, Izmir Faculty of Medicine Tepecik Training and Research Hospital, Izmir, Turkey.
This study aims to determine the necessary preventive measures from the perspective of primary care by examining the demographic characteristics and initial diagnoses of patients who were evaluated by an ophthalmologist following an emergency consultation request. Individuals over the age of 18 who had complete data and were referred for ophthalmic consultation from the emergency department within in 2022 were included in the study. The study retrospectively reviewed the patients' age, gender, diagnoses, status of ophthalmic consultation, whether a forensic report was prepared, and the outcomes of follow-up, hospitalization, or discharge.
View Article and Find Full Text PDFSurface moieties drive the superior protection of curcumin-derived carbon quantum dots against retinal ischemia-reperfusion injury.
J Mater Chem B
March 2025
Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan.
Despite the recognized neuroprotective benefits of curcumin, its clinical utility is constrained by poor bioavailability and high cytotoxicity at effective doses. This study evaluates the therapeutic potential of curcumin-derived carbon quantum dots (Cur-CQDs) for retinal protection against ischemia-reperfusion (IR) injury in rats. Cur-CQDs were synthesized mild pyrolysis at varying temperatures and assessed for efficacy in rat retinal ganglion cells and a model of retinal IR injury.
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