Post-traumatic amnesia (PTA) is a common symptom of acute traumatic brain injury (TBI). The Galveston Amnesia and Orientation Test (GOAT) and Orientation-Log (O-Log) are commonly used assessment tools to evaluate PTA following TBI. In this study, we aimed to validate the Persian versions of both scales. The forward-backward translation method was used, and a panel of experts, including three neuroscientists, one epidemiologist, and four lay experts with TBI experience, evaluated the scales. A total of 140 mild TBI patients aged 12 years and older were subsequently assessed with scales. Reliability was assessed using two approaches including Cronbach's Alpha and Intraclass Correlation Coefficient (ICC). The total ICCs were 0.870 (95% CI: 0.818-0.907) and 0.687 (95% CI: 0.564-0.776) for the GOAT and O-Log, respectively. The Cronbach's alpha values for the GOAT and O-Log were 0.64 and 0.75, respectively. A significant correlation was also found between the GOAT score and the O-Log (r = 0.729, p < 0.001). The Persian GOAT and O-Log were validated as reliable tools for monitoring TBI patients' orientation. The interviews revealed significant cultural considerations that must be considered when the scales are translated and validated to ensure their validity and reliability in diverse cultural contexts and prevent bias.
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http://dx.doi.org/10.1038/s41598-025-85923-1 | DOI Listing |
Epidemiol Psychiatr Sci
March 2025
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Aims: To examine the risk of perinatal mental illness, including new diagnoses and recurrent use of mental healthcare, comparing women with and without traumatic brain injury (TBI), and to identify injury-related factors associated with these outcomes among women with TBI.
Methods: We conducted a population-based cohort study in Ontario, Canada, of all obstetrical deliveries to women in 2012-2021, excluding those with mental healthcare use in the year before conception. The cohort was stratified into women with no remote mental illness history (to identify new mental illness diagnoses between conception and 365 days postpartum) and those with a remote mental illness history (to identify recurrent illnesses).
Psychol Med
March 2025
Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Background: Population-level preventive interventions are urgently needed and may be effective for psychosis due to social determinants. We tested three syndemic models along pathways from childhood adversity (CA) to psychotic spectrum disorder (PSD) and their implications for prevention.
Methods: Cross-sectional data from 7461 British men surveyed in 5 population subgroups.
Int J Mol Sci
February 2025
Touro College of Osteopathic Medicine, Touro University, Great Falls, MT 59405, USA.
The () gene encodes a neutral amino acid transporter, also referred to as alanine-serine-cysteine transporter 1, ASCT1, that helps maintain amino acid balance in the brain and periphery. In the brain, SLC1A4 plays an important role in transporting levo (L) and dopa (D) isomers of serine. L-serine is required for many cellular processes, including protein and sphingolipid synthesis, while D-serine is a co-agonist required for normal neurotransmission through -methyl-D-aspartate receptors.
View Article and Find Full Text PDFDiagnostics (Basel)
March 2025
Digital Technology & Health Information, Roche Information Solutions, 2841 Scott Blvd, Santa Clara, CA 95050, USA.
In a rapidly changing technology landscape, "Clinical Decision Support" (CDS) has become an important tool to improve patient management. CDS systems offer medical professionals new insights to improve diagnostic accuracy, therapy planning, and personalized treatment. In addition, CDS systems provide cost-effective options to augment conventional screening for secondary prevention.
View Article and Find Full Text PDFDiagnostics (Basel)
March 2025
Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
This study used diffusion tensor imaging (DTI) to detect brain microstructural changes in participants with mild traumatic brain injury (mTBI) who experienced post-traumatic headaches, a common issue that affects quality of life and rehabilitation. Despite its prevalence, the mechanisms behind post-traumatic headache are not well understood. Participants were recruited from Level 1 trauma centers, and MRI scans, including T1-weighted anatomical imaging and DTI, were acquired 1 month post-injury.
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