Cardiovascular diseases (CVD) are a predominant health concern globally, emphasizing the need for advanced diagnostic techniques. In our research, we present an avant-garde methodology that synergistically integrates ECG readings and retinal fundus images to facilitate the early disease tagging as well as triaging of the CVDs in the order of disease priority. Recognizing the intricate vascular network of the retina as a reflection of the cardiovascular system, alongwith the dynamic cardiac insights from ECG, we sought to provide a holistic diagnostic perspective. Initially, a Fast Fourier Transform (FFT) was applied to both the ECG and fundus images, transforming the data into the frequency domain. Subsequently, the Earth Mover's Distance (EMD) was computed for the frequency-domain features of both modalities. These EMD values were then concatenated, forming a comprehensive feature set that was fed into a Neural Network classifier. This approach, leveraging the FFT's spectral insights and EMD's capability to capture nuanced data differences, offers a robust representation for CVD classification. Preliminary tests yielded a commendable accuracy of 84%, underscoring the potential of this combined diagnostic strategy. As we continue our research, we anticipate refining and validating the model further to enhance its clinical applicability in resource limited healthcare ecosystems prevalent across the Indian sub-continent and also the world at large.
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http://dx.doi.org/10.1038/s41598-025-87634-z | DOI Listing |
Curr Eye Res
March 2025
Department of Ophthalmology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Purpose: This study aims to describe an innovative suprachoroidal space injection technique using a combination of 30 G and 22 G needles attached to a 1 ml injector. The efficacy and applicability of this technique in suprachoroidal injections are evaluated.
Methods: In this study, we conducted both and injection experiments using isolated porcine eyes and live SD rats, respectively.
BMC Ophthalmol
March 2025
Eye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, 226001, China.
Pre-diabetes is the preceding condition of diabetes, and in some cases, fundus changes have been seen in pre-diabetes. The inflammatory response is widely recognized as being involved in the pathophysiologic process of diabetic eye disease. Therefore, we aimed to acquire understanding of the role of early altered blood glucose levels in the development and etiology of diabetic ocular disorders from the perspective of inflammation.
View Article and Find Full Text PDFBMC Med Imaging
March 2025
School of Electronics Engineering, Vellore Institute of Technology, Vellore, India.
Background: Diabetic retinopathy is a major cause of vision loss worldwide. This emphasizes the need for early identification and treatment to reduce blindness in a significant proportion of individuals. Microaneurysms, extremely small, circular red spots that appear in retinal fundus images, are one of the very first indications of diabetic retinopathy.
View Article and Find Full Text PDFAm J Ophthalmol
March 2025
Moorfields Eye Hospital NHS Foundation Trust, London, UK; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK.
Objective: To identify genetic determinants specific to reticular pseudodrusen (RPD) compared with drusen.
Design: Genome-wide association study (GWAS) SUBJECTS: Participants with RPD, drusen, and controls from the UK Biobank (UKBB), a large, multisite, community-based cohort.
Methods: A deep learning framework analyzed 169,370 optical coherence tomography (OCT) volumes to identify cases and controls within the UKBB.
Comput Biol Med
March 2025
The AIM for Health Lab, Monash University, Melbourne, Australia; Faculty of Information Technology, Monash University, Melbourne, Australia. Electronic address:
Objective: To resolve the underestimation problem and investigate the mechanism of the AI model which employed to predict cardiovascular disease (CVD) risk scores from retinal fundus photos.
Methods: An ordinal regression Deep Learning (DL) model was proposed to predict 10-year CVD risk scores. The mechanism of the DL model in understanding CVD risk was explored using methods such as transfer learning and saliency maps.
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