Individualized prediction of multi-domain intelligence quotient in bipolar disorder patients using resting-state functional connectivity.

Background: Although accumulating studies have explored the neural underpinnings of intelligence quotient (IQ) in patients with bipolar disorder (BD), these studies utilized a classification/comparison scheme that emphasized differences between BD and healthy controls at a group level. The present study aimed to infer BD patients' IQ scores at the individual level using a prediction model.

Methods: We applied a cross-validated Connectome-based Predictive Modeling (CPM) framework using resting-state fMRI functional connectivity (FCs) to predict BD patients' IQ scores, including verbal IQ (VIQ), performance IQ (PIQ), and full-scale IQ (FSIQ). For each IQ domain, we selected the FCs that contributed to the predictions and described their distribution across eight widely-recognized functional networks. Moreover, we further explored the overlapping patterns of the contributed FCs for different IQ domains.

Results: The CPM achieved statistically significant prediction performance for three IQ domains in BD patients. Regarding the contributed FCs, we observed a widespread distribution of internetwork FCs across somatomotor, visual, dorsal attention, and ventral attention networks, demonstrating their correspondence with aberrant FCs correlated to cognition deficits in BD patients. A convergent pattern in terms of contributed FCs for different IQ domains was observed, as evidenced by the shared-FCs with a leftward hemispheric dominance.

Conclusions: The present study preliminarily explored the feasibility of inferring individual IQ scores in BD patients using the FCs-based CPM framework. It is a step toward the development of applicable techniques for quantitative and objective cognitive assessment in BD patients and contributes novel insights into understanding the complex neural mechanisms underlying different IQ domains.