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A "Civity" Approach Helps Build the Civic Muscle That Underlies Healthy Communities.
Am J Public Health
April 2025
Palma Joy Strand is with the nonprofit organization Civity, San Francisco, CA, emerita professor at Creighton University, Omaha, NE, and visiting professor at Marquette University School of Law, Milwaukee, WI. Malka Ranjana Kopell is with the nonprofit organization Civity, San Francisco, CA, and California State University, Sacramento, CA.
Muscle transcriptome profiles in elite male ultra-endurance athletes acclimated to a high-carbohydrate versus low-carbohydrate diet.
Sci Rep
March 2025
Department of Human Sciences, The Ohio State University, Columbus, OH, USA.
Low-carbohydrate, high-fat diets enhance lipid metabolism and decrease reliance on glucose oxidation in athletes, but the associated gene expression patterns remain unclear. The purpose of this study was to determine whether coordinated molecular pathways in skeletal muscle may be revealed by differential expression of genes driven by dietary profile, exercise, and/or their interaction. We investigated the skeletal muscle transcriptome in elite ultra-endurance athletes habitually (~ 20 months) consuming a high-carbohydrate, low-fat (HC, n = 10, 33 ± 6y, VO2max = 63.
View Article and Find Full Text PDFIntegrative multi-omics analysis of metabolic dysregulation induced by occupational benzene exposure in mice.
Sci Total Environ
March 2025
Department of Biological Sciences, Integrative Biosciences Center (IBio), Wayne State University, Detroit, MI, USA; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA. Electronic address:
Type 2 Diabetes Mellitus (T2DM) is a significant public health burden. Emerging evidence links volatile organic compounds (VOCs), such as benzene to endocrine disruption and metabolic dysfunction. However, the effects of chronic environmentally relevant VOC exposures on metabolic health are still emerging.
View Article and Find Full Text PDFEvaluation of Bi-layer Silk Fibroin Grafts for Onlay Urethroplasty in a Female Porcine Model of Long Urethral Strictures.
Tissue Eng Regen Med
March 2025
Department of Urology, University of California, Irvine, Building 55, 101 The City Drive South., Rm. 300, Orange, CA, 92868, USA.
Background: Buccal mucosa urethroplasty represents the primary strategy for reconstruction of long urethral strictures (US). However, significant complications including stricture recurrence and donor site morbidity currently hamper this approach. The goal of this study was to determine the efficacy of acellular, bi-layer silk fibroin (BLSF) biomaterials to serve as superior alternatives to buccal mucosal (BM) grafts for repair of 4 cm long US in female swine.
View Article and Find Full Text PDFBackground: Our current study builds on our recent report that showed Palmitate aggravates ischemic endothelial (EC) dysfunction and aims to determine whether Palmitate is a critical determinant of PAD severity. In contrast to Palmitate, we studied the role of short-chain fatty acids (SCFAs) in regulating ischemic revascularization in PAD.
Methods: Femoral artery ligation and resection was used as preclinical-PAD model.
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