. PDD and profile curves play a crucial role in analyzing the beam quality and energy stability of accelerators. The aim of this study was to assess the efficacy of GPR in machine QA and compare it with traditional methods for analyzing dose outputs.. GPRs were employed to assess the quality of radiation beams by comparing 1D and 2D Profile metrics and PDD data against commissioning data. The data used were obtained from the ASCII data files derived from the water tank. GPRs were calculated for all plots with a lower percentage dose cutoff of 10%. The local GPRs and dose influence for the 2D PDD metrics and dose influence were calculated for an open field 10 × 10 cmphoton beam at SSD = 100 cm. In both 1D and 2D GPRs analyses, criterion of 1%/1 mm was adopted, as this approach allows for the capture of more subtle variations in the data. To substantiate the viability of the study, a comparative analysis was conducted by comparing the outcomes of the gamma analysis with those derived from traditional methods, such as manual machine quality assurance checks.. GPRs demonstrated a superior capability for comprehensive data analysis compared to traditional methods. For the 1D curves, the passing rates (≤ 1) are 96.19%, 100%, and 93.46%, respectively. With respect to the 2D dose influence, the PDD image passing rate was 99.57%, and significant dose differences were observed at the four corners of the open field, indicating areas that require further investigation.. Compared to traditional methods, GPRs are more sensitive to subtle changes in the data, providing valuable insights into the accelerator beam status.
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http://dx.doi.org/10.1088/2057-1976/adb291 | DOI Listing |
Curr Eye Res
March 2025
Department of Ophthalmology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Purpose: This study aims to describe an innovative suprachoroidal space injection technique using a combination of 30 G and 22 G needles attached to a 1 ml injector. The efficacy and applicability of this technique in suprachoroidal injections are evaluated.
Methods: In this study, we conducted both and injection experiments using isolated porcine eyes and live SD rats, respectively.
Rev Esp Enferm Dig
March 2025
School of Traditional Chinese Medicine, Ningxia Medical University.
Background And Aims: The relationship between irritable bowel syndrome (IBS) and structural changes in various regional cortical areas remains unclear. Mendelian randomization (MR) was used to explore the potential association between IBS and Structural Brain Changes.
Methods: Genetically independent loci associated with IBS in individuals of European ancestry were selected as instrumental variants (IVs) in the large-scale genome-wide association studies (GWAS).
Geriatr Gerontol Int
March 2025
Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Aim: Rehospitalization of patients with heart failure (HF) incurs high health care costs and increased mortality. Infection-related rehospitalizations in patients with HF occur frequently, and the risk increases with age. This study aimed to identify the factors associated with infection-related rehospitalizations in older patients with HF.
View Article and Find Full Text PDFPsychol Med
March 2025
Centre for Innovation in Mental Health, School of Psychology, University of Southampton, Southampton, UK.
Background: It is unknown whether there is a general factor that accounts for the propensity for both physical and mental conditions in different age groups and how it is associated with lifestyle and well-being.
Methods: We analyzed health conditions data from the Millennium Cohort Study (MCS) (age = 17; N = 19,239), the National Child Development Study (NCDS) (age = 44; N = 9293), and the English Longitudinal Study of Ageing (ELSA) (age ≥ 50; N = 7585). The fit of three Confirmatory Factor models was used to select the optimal solution by Comparative Fit Index, Tucker-Lewis Index, and Root Mean Square Error of Approximation.
Front Immunol
March 2025
Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Background: Osteosarcoma, an aggressive bone malignancy predominantly affecting children and adolescents, presents significant therapeutic challenges with a 5-year survival rate below 30% in metastatic cases. T-cell exhaustion, characterized by the overexpression of immune checkpoint molecules, contributes to osteosarcoma progression and immune evasion. Although targeting these inhibitory pathways has shown potential in restoring T-cell activity, the molecular regulators of T-cell depletion in osteosarcoma are poorly understood.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!