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The term "local electrical stimulation" means the delivery, for therapeutic purposes, of electric current signals in the areola of the projections of acupuncture points. Among the varieties of this effect are electro- and electroacupuncture, as well as transcutaneous electrical neurostimulation. In the case of electropuncture, minimal skin areas are irritated, outside of the damage, by placing the sensors according to the projections of the points. In the electroacupuncture, current signals are sent to steel needles immersed in tissues, ensuring the activation of not only skin afferents, but also deeper afferents. Percutaneous stimulation consists of irritating large areas of the skin with the help of portable devices. The paper reveals the mechanisms underlying the therapeutic effect of these methods, and puts forward an assumption about the prevailing biological significance of low-intensity stimuli. In addition, specific examples of use of local electrical stimulation in a number of pathological conditions are also presented.
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http://dx.doi.org/10.4081/ejtm.2025.13305 | DOI Listing |
J Biol Chem
March 2025
Department of Neurology, Yale School of Medicine, New Haven, CT, USA; Center for Neuroscience & Regeneration Research, Yale University, West Haven, CT, USA; Neuro-Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA. Electronic address:
Voltage-gated sodium (Nav) channels are critical for electrical signaling, and their pharmacological modulation can be leveraged for the development of therapeutic agents targeting various disorders. The local anesthetic (LA) site on Nav channels is particularly important, as it is a common target for many clinically used inhibitors, including anticonvulsants and antiarrhythmics. Our goal was to identify novel Nav channel inhibitors by leveraging physicochemical criteria, focusing on potential LA site binding candidates.
View Article and Find Full Text PDFExp Eye Res
March 2025
Department of Ophthalmology, Duke University, Durham, North Carolina.
A greater understanding of the pathophysiology of AMD has yielded potential therapeutic strategies for slowing vision loss. Structural imaging biomarkers and novel functional outcomes, both under intensive study as surrogate endpoints in AMD clinical trials, are new granular tools needed to assess disease progression and follow response to therapy. These advances have created, for the first time, the possibility to intervene early in AMD, and to measure success in a time frame feasible for clinical trials.
View Article and Find Full Text PDFJ Colloid Interface Sci
March 2025
College of Materials Science and Engineering of Shenzhen University, Shenzhen 518061, China. Electronic address:
The development of cathode materials with fast kinetics and excellent cycling stability is essential to fully utilize the safety and economic advantages of aqueous zinc-ion batteries (AZIBs). In this study, a facile solvothermal route was designed to synthesize oxygen vacancy-rich CuVO·nHO (CVO-0.1) cathode materials.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Research and Publications, Kampala International University, P.O. Box 20000, Kampala, Uganda.
The increasing demand for sustainable energy solutions has highlighted the need to optimize solar power generation systems. While solar power has been extensively studied, the influence of local wind flow on solar irradiance and power generation remains underexplored. This study addresses this gap by developing a differential model that incorporates both solar irradiance and wind flow effects to enhance the prediction of solar power generation across various regions in Uganda.
View Article and Find Full Text PDFNat Commun
March 2025
IBM Quantum, IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
Interacting many-body quantum systems and their dynamics, while fundamental to modern science and technology, are formidable to simulate and understand. However, by discovering their symmetries, conservation laws, and integrability, one can unravel their intricacies. Here, using up to 124 qubits of a fully programmable quantum computer, we uncover local conservation laws and integrability in one- and two-dimensional periodically-driven spin lattices in a regime previously inaccessible to such detailed analysis.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!