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Proceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation.
Lancet Oncol
March 2025
Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.
Radiotherapy both promotes and antagonises tumour immune recognition. Some clinical studies show improved patient outcomes when immunotherapies are integrated with radiotherapy. Safe, greater than additive, clinical response to the combination is limited to a subset of patients, however, and how radiotherapy can best be combined with immunotherapies remains unclear.
View Article and Find Full Text PDFThe Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies.
Research (Wash D C)
March 2025
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis and cancer progression. Aging is a well-established primary risk factor for cancer, while disruptions in circadian rhythms are intricately associated with the tumorigenesis and progression of various tumors. Moreover, aging itself disrupts circadian rhythms, leading to physiological changes that may accelerate cancer development.
View Article and Find Full Text PDFUnderstanding the emotional dynamics within social interactions is crucial for meaningful interpretation. Despite progress in emotion recognition systems, recognizing the collective emotional climate among peers has been understudied. Addressing this gap, we propose EmoNet, an AI model transcending traditional emotion identification.
View Article and Find Full Text PDFSurviving the storm: exploring gender-based burnout in Lebanon during the COVID-19 pandemic.
Front Public Health
March 2025
Department of Pharmacy Practice, School of Pharmacy, Lebanese American University, Byblos, Lebanon.
Background: COVID-19 has worsened burnout, marked by exhaustion, cynicism, and reduced professional efficacy. In Lebanon, economic collapse, political instability, the Beirut Port explosion, and social unrest have compounded this, with limited gender-specific data. This study evaluates burnout levels in Lebanese women and men during COVID-19, exploring gender differences and related factors, including burnout mitigation strategies.
View Article and Find Full Text PDFMaking the public protect public health: the ethics of promoting collective action in emergencies.
J Med Ethics
March 2025
Australian Centre for Health Engagement, Evidence and Values, University of Wollongong, Wollongong, New South Wales, Australia.
Effective public health responses to many infectious diseases require sustained collective action. Communicable disease control in populations can only be achieved by high levels of public compliance with health directives. However, governing authorities have limited options if public compliance is insufficient and collective action is failing.
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