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3D Model of Human Epidermis Exposed to Staphylococci Reveals Keratinocyte Responses Unique to Atopy-Associated S. aureus Challenge.
Allergy
March 2025
Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Anagen Effluvium in a Child Misusing Methotrexate: A Case Report With Dermoscopic Findings.
Pediatr Dermatol
March 2025
Department of Dermatology, Ankara Etlik City Hospital, Ankara, Turkey.
Anagen effluvium is a rare adverse effect of methotrexate therapy, generally associated with high-dose regimens. We report a 12-year-old girl who developed abrupt hair loss 1 week after inadvertently taking methotrexate 15 mg daily for five consecutive days (total 75 mg), without other signs of systemic toxicity. Trichoscopic examination and trichogram findings confirmed methotrexate-induced anagen effluvium, and spontaneous hair regrowth occurred after 2 months.
View Article and Find Full Text PDFPosterior cervical instrumented fusion case complicated by acute generalized erythematous pustulosis.
J Surg Case Rep
March 2025
Department of Neurosurgery, Neurosurgery, The Walton Centre NHS Foundation Trust, Lower Lane, Liverpool L9 7LJ, United Kingdom.
This case report describes the first case of acute generalised erythematous pustulosis (AGEP) following cervical spinal surgery. A 74-year-old male post-operatively developed a painful, exudative bullous rash progressing from the posterior cervical wound site. Initial management with antibiotics for suspected cellulitis failed, leading to further investigation and a diagnosis of AGEP by dermatology.
View Article and Find Full Text PDFBiomarkers to aid in diagnosis of allergic contact dermatitis.
Front Allergy
February 2025
Department of Pathology, Microbiology, & Immunology, New York Medical College, Valhalla, NY, United States.
Allergic contact dermatitis (ACD) is an increasingly common skin condition characterized by itchy rashes in response to allergens. The most common diagnostic test involves patch testing (PT), but despite the efficacy of PT for identifying and guiding patients toward avoidance of allergens, PT alone does not elucidate the underlying biomechanistic changes which may be useful for sub-categorizing ACD further. In addition, some patients may never be able to identify their causative allergens unless they go to highly specialized ACD centers.
View Article and Find Full Text PDFFrom the Masterclasses in Dermatology 2024 Meeting: Updates in Psoriasis Treatments.
J Clin Aesthet Dermatol
February 2025
Ms. Romanelli and Dr. Gottlieb are with the Department of Dermatology and Department of Medicine, Division of Rheumatology at Icahn School of Medicine at Mount Sinai in New York, New York.
Psoriasis (PsO) is an immune-mediated, chronic inflammatory skin disease that significantly impairs quality of life. Its treatment landscape is rapidly evolving, providing better disease control. Here, we highlight updates in biologics, obtaining coverage for biologics under Medicare, the PsO-to-psoriatic arthritis (PsA) transition, and orally administered drugs, as presented at the 2024 Masterclass in Dermatology in Puerto Rico.
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