The composition of bile acids in the B and C portions of the duodenal juice of six essentially healthy test subjects exposed to 120-day head-down bed rest was investigated. As the exposure continued, the percentage content of bile acids conjugated with taurine increased and that of bile acids conjugated with glycine decreased. The rapid and significant decrease of the ratio of glycine conjugated to taurine conjugated bile acids suggests a specific modification of the synthetic function of hepatocytes under the above conditions.
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