Background: Invasive infections by Nocardia farcinica, Aspergillus species (spp.) and Candida dubliniensis are rare infectious complications in patients diagnosed with multiple myeloma.
Case Presentation: In this case report, we describe a patient who received three lines of therapy, with proteasome inhibitors, corticosteroids, cyclophosphamide and lenalidomide, and who was concurrently infected with these three opportunistic pathogens. A blood stream infection with C. dubliniensis was treated with 4 weeks of anidulafungin. Aspergillus spp. was treated for 12 weeks with voriconazole. N. farcinica treatment was continued indefinitely with co-trimoxazole and moxifloxacin after regression at discharge of brain abscesses and the pulmonary aspergilloma.
Conclusion: The diagnostic challenges and management in this particularly vulnerable patient are highlighted.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789363 | PMC |
| http://dx.doi.org/10.1186/s12879-024-10387-z | DOI Listing |
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