The effect of intraperitoneal noradrenaline injection (2.5 mg/kg body weight) on myocardial levels of cAMP, cHMP, PGE and PGF2 alpha of the left and right ventricles was examined in male Wistar rats. The findings were compared with morphologic changes in the myocardium and sympathetic nerves of both ventricles. Cyclic nucleotides and PGs were measured by RIA, sympathetic nerves, by a fluorescent histochemical technique; myocardial lesions were demonstrated by Lie-staining. A sharp drop was noted in cAMP and PG levels at early stages of the experiment followed by a gradual return to control values. The decrease in cAMP was less marked, and more transient, in the right ventricle. These changes were accompanied with a more pronounced damage to the left ventricle, perhaps due to differences in adrenergic innervation as well as cyclic nucleotides and PG metabolism in the examined compartments of the heart.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Stellate ganglion blockade under ultrasound-guidance and the physiological responses in the rat.
Front Physiol
January 2025
Susan Samueli Integrative Health Institute and Department of Medicine, University of California, Irvine, Irvine, CA, United States.
Stellate ganglion blockade (SGB) is a practical approach to managing many clinical disorders. Ultrasound-guided SGB is currently adopted as a more effective and safer method in humans. Developing this technique in rats would facilitate further study of SGB application.
View Article and Find Full Text PDFEfficacy of Neuro-muscular Electrical Stimulation for Orthostatic Hypotension Associated with Long-term Disuse and Diabetic Autonomic Neuropathy: A Case Report.
Phys Ther Res
August 2024
Department of Internal Medicine, Sanseikai Kitano Hospital, Japan.
Unlabelled: Patient Background: A 75-year-old man had difficulty moving around at home because of loss of appetite and neglect of medication for several days. He was brought to the emergency room and admitted on the same day with a diagnosis of dehydration and diabetic ketoacidosis. He started physical therapy (PT), had frequent fainting and presyncope due to hypotension, and had difficulty leaving bed.
View Article and Find Full Text PDFThe growing complexity of the control of the hypothalamic pituitary thyroid axis and brown adipose tissue by leptin.
Vitam Horm
January 2025
Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, United States. Electronic address:
The balance between food intake and energy expenditure is precisely regulated to maintain adipose stores. Leptin, which is produced in and released from adipose in direct proportion to its size, is a major contributor to this control and initiates its homeostatic responses largely via binding to leptin receptors (LepR) in the hypothalamus. Decreases in hypothalamic LepR binding signals starvation, leading to hunger and reduced energy expenditure, whereas increases in hypothalamic LepR binding can suppress food intake and increase energy expenditure.
View Article and Find Full Text PDFPros and cons of surgical versus conservative management for head and neck paraganglioma: a real-world data analysis.
Endocrine
January 2025
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy.
Purpose: To compare functional deficits associated to surgery with those caused by the growth of the head and neck paragangliomas (HNPGLs).
Methods: 72 patients with HNPGLs were included. Patients were divided in group A (49 patients undergoing surgery) and group B (23 patients following a wait and see approach).
Dapagliflozin increased pancreatic beta cell proliferation and insulinogenic index in mice fed a high-fat and high-sodium chloride diet.
Biochem Biophys Res Commun
January 2025
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan.
People in Eastern Asia, including Japan, traditionally consume higher amounts of sodium chloride than in the United States and Western Europe, and it is common knowledge that impaired insulin secretion-rather than insulin resistance-is highly prevalent in Asian people who have diabetes mellitus. We previously reported that mice fed a high-fat and high-sodium chloride (HFHS) diet had a relatively lower degree of obesity than mice fed a high-fat diet, but had a comparatively impaired insulin secretion. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been shown to dampen down the sympathetic nervous system, which reportedly is activated by a high-sodium chloride diet.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!