Background: Surgical repair for high anal fistulas is challenging and can be associated with impaired functional outcomes. This study evaluated the long-term results of transsphincteric fistulectomy with primary sphincter repair for high anal fistulas in terms of recurrence, wound healing, fecal incontinence, and quality of life.
Method: This retrospective cohort study included patients who underwent surgical repair for high anal fistulas between 2006 and 2015. Data were collected by reviewing patients' electronic hospital records, including demographic characteristics, medical conditions, surgical findings, performed procedures, and follow-up data until the last recorded visit. Functional outcomes were assessed using self-reported online questionnaires for quality of life (RAND SF-36) and fecal incontinence (Wexner score).
Results: Fifty-five patients were included. Primary healing was achieved in 42 (76%) patients, while 13 (24%) experienced recurrence. Following reoperations for recurrence, an additional 12 patients achieved healing, resulting in an overall healing rate of 98%. The median Wexner score was significantly higher in reoperated patients, and the median scores across all eight parameters of the RAND SF-36 were lower. None of the patients required proctectomy, and two ended with permanent stomas.
Conclusion: Surgery for high anal fistulas is associated with a high success rate, but reoperations for recurrence are linked to considerable impairment in functional outcomes.
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http://dx.doi.org/10.1007/s00464-025-11585-9 | DOI Listing |
Anal Chem
March 2025
School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Ji'nan 250012, China.
Sweat, as a metabolic byproduct, encompasses a diverse array of molecular information pertinent to our physiological states and overall health. The extraction of minute quantities of sweat, coupled with sensitive monitoring and identification of its internal molecular components, constitutes an effective strategy for assessing bodily conditions. We engineer a Janus membrane utilizing electrospinning techniques for application on human skin to facilitate sweat collection.
View Article and Find Full Text PDFAnal Chem
March 2025
Shandong Key Laboratory of Biophysics, Institute of Biophysics, Institute of Rural Revitalization, School of Pharmacy, Dezhou University, 253023 Dezhou, China.
Peripheral blood circulating tumor DNA (ctDNA) is a crucial liquid biopsy biomarker that correlates overall systemic tumor burden with malignant progression. However, identifying multiple single nucleotide polymorphisms (SNPs) in ctDNA presents significant challenges. In this study, we developed a rolling circle amplification (RCA)-supported multipedal DNA walker integrated with toehold-mediated strand displacement (TSDR) to facilitate the detection of ctDNA SNPs.
View Article and Find Full Text PDFLakartidningen
March 2025
docent, överläkare, Karolins-ka universitetssjukhuset, Stockholm.
HPV-related cancers in men, particularly anal and oropharyngeal cancers, are increasing in Sweden and globally. Men who have sex with men, trans persons and people living with HIV are at especially high risk. HPV vaccination effectively prevents HPV infection and related precancers when given up to age 26.
View Article and Find Full Text PDFAnal Chem
March 2025
Department of Chemistry, Atomic and Mass Spectrometry - A&MS Research Group, Ghent University, Campus Sterre, Krijgslaan 281-S12, Ghent 9000, Belgium.
Novel low-dispersion ablation cell designs and highly efficient aerosol transport systems have enabled fast elemental mapping using laser ablation-ICP-mass spectrometry (LA-ICP-MS) at high spatial resolution and its application in various research fields. Nowadays, the fastest low-dispersion setups enable narrow single pulse responses (SPR, duration of the transient signal observed upon a single laser shot), which enhance the signal-to-noise ratio and boost the pixel acquisition rate attainable in elemental mapping applications. In this work, the analytical performance of a nanosecond 193 nm ArF* excimer-based kHz laser in combination with a low-dispersion tube-type ablation cell, coupled to an ICP-mass spectrometer equipped with a time-of-flight (ToF) analyzer, was evaluated.
View Article and Find Full Text PDFCytopathology
March 2025
Centre National de Pathologie, Laboratoire National de Santé, Dudelange, Luxembourg.
Introduction: Recent studies have shown that digital cytology (DC) coupled with artificial intelligence (AI) algorithms is a valid approach to the diagnosis of cervico-vaginal lesions using liquid-based cytology (LBC). We evaluated the use of these methods for anal LBC specimens.
Methods: A series of 124 anal LBC slides previously diagnosed by conventional microscopy (CC) were reviewed with a DC/AI system that generated a gallery of images.
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