Objective: To study the clinical curative effects of Angong Niuhuang Pills in the treatment of severe heat stroke and its influence on the rescue efficiency of patients.
Methods: A total of 76 patients with severe heat stroke who were treated in our hospital were selected from January 2021 to December 2022. According to the sequence of admission, 38 patients in the control group (2021.1-12) received comprehensive western medicine therapy, and 38 sufferers in the observation group (2022.1-12) received Angong Niuhuang Pills on this basis. The body temperature monitoring results at 120 minutes after admission, inflammatory factor levels, relevant biochemical indicators, brain injury indicators, acute physiology and chronic health evaluation system II (APACHE II) score, clinical curative effect, clinical related recovery indicators, and the occurrence of organ function damage were compared between the 2 groups.
Results: The body temperature of patients in the observation one was less than that of the control one at 60 minutes, 90 minutes, and 120 minutes after admission, and the distinction had statistical significance (all P < .05); after the therapy, the levels of IL-1, IL-6, hs-CRP, TNF-α, ALT, BUN, Cr, MYO, S-100β protein, NSE, APACHEII score were all lower than those of the control one, and the distinction had statistical significance (all P < .05); the total clinical effective rate of the observation group (97.37%) was higher than that of the control group (81.58%), the recovery time of consciousness, rectal temperature recovery time and length of stay were all shorter than the control group, and the incidence of organ function damage (7.89%) was less than that of the control one (26.32%), and the distinction had statistical significance (all P < .05).
Conclusion: Angong Niuhuang Pills are safe and effective in the treatment of severe heatstroke sufferers, and can make the patients' body temperature return to the normal range in a short time, help to reduce inflammation reactions and play a protective role in the brain, and can shorten the recovery time of patients' consciousness and length of stay, with relatively high rescue efficiency.
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Article Synopsis
- Angong Niuhuang Wan (AGNHW) is a traditional Chinese medicine from the Qing dynasty, aimed at treating brain edema caused by infections and ischemia, but its effects on LPS-induced vascular brain edema were previously unclear.
- This study tested AGNHW's impact on LPS-induced cerebrovascular edema in mice through various measures, including survival rate, cerebral water content, and protein expression.
- Results showed that AGNHW improved survival, reduced cerebral edema, and enhanced certain protein expressions while influencing multiple phosphorylated proteins and revealing 11 AGNHW metabolites in the blood.
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