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Wunderlich syndrome (WS), characterized by spontaneous nontraumatic renal or perinephric hemorrhage, presents a significant diagnostic challenge due to its varied causes and clinical manifestations. Despite its historically high case fatality rate, prompt and accurate diagnosis combined with a multidisciplinary treatment approach has been shown to significantly improve patient outcomes. This case series discusses three patients with diverse presentations of WS, each managed with tailored therapeutic strategies involving a combination of conservative management, super selective renal artery embolization, and surgical interventions such as nephrectomy.

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The incidence of bacterial infections is high in patients with liver cirrhosis (LC) due to compromised immune systems. They are associated with acute hepatic decompensation, multiorgan dysfunction, high morbidity, and mortality and account for 25-46% of all hospitalizations. The mortality rate is about 30% after one month and increases to 63% at one-year follow-up.

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Introduction: Nontraumatic biliary rupture and retroperitoneal biloma infrequently occur. Here, we report a case of retroperitoneal biloma due to spontaneous left hepatic duct perforation, which was difficult to differentiate from a perirenal abscess.

Case Presentation: A 94-year-old female patient was hospitalized with symptoms of fatigue and right back pain that lasted for 5 days.

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Wunderlich syndrome (WS) is characterized by spontaneous renal or perinephric hemorrhage in the absence of known trauma. WS is much rarer than haemorrhage caused by iatrogenic or traumatic conditions. The classic WS presentation of Lenk's triad of acute onset flank pain, flank mass, and hypovolemic shock is seen in less than a quarter of patients.

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