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Background: The epoxyeicosatrienoic acids (EETs) are derivatives of the arachidonic acid metabolism with anti-inflammatory activities. However, their efficacy is limited due to the rapid hydrolysis by the soluble epoxide hydrolase (sEH). Accordingly, inhibition of sEH has been shown to stabilize the EETs and dampen neuroinflammation in Ab mouse models of Alzheimer's disease (AD).
View Article and Find Full Text PDFPruning functional connections in human induced pluripotent stem cell derived neural networks.
Annu Int Conf IEEE Eng Med Biol Soc
July 2024
The failure of human neuronal stem cells to integrate with brain tissue suggests the need to provide functional cues to modify and re-organize the existing naive network. Understanding how human neural networks respond to external stimuli is crucial to realizing this goal. Here, we stimulate a human induced pluripotent stem cell (hIPSC)-derived neural network on a microelectrode array in a Hebbian fashion to explore the resulting network changes.
View Article and Find Full Text PDFBioprinting functional hepatocyte organoids derived from human chemically induced pluripotent stem cells to treat liver failure.
Gut
March 2025
Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, People's Republic of China
Background: To treat liver failure, three-dimensional (3D) bioprinting is a promising technology used to construct hepatic tissue models. However, current research on bioprinting of hepatic tissue models primarily relies on conventional single-cell-based bioprinting, where individual functional hepatocytes are dispersed and isolated within hydrogels, leading to insufficient treatment outcomes due to inadequate cell functionality.
Objective: Here, we aim to bioprint a hepatic tissue model using functional hepatocyte organoids (HOs) and evaluate its liver-specific functions and .
Integrin stimulation by collagen I at the progenitor stage accelerates maturation of human iPSC-derived cardiomyocytes.
J Mol Cell Cardiol
February 2025
Department of Chemical Engineering, University of Puerto Rico-Mayagüez, Call Box 9000, Mayagüez, PR 00681-9000, United States.. Electronic address:
Cell manufacturing challenges have hampered effective preclinical evaluations of mature cardiac cells derived from human-induced pluripotent stem cells (hiPSCs). These challenges mainly stem from standard differentiation methods yielding cardiac cells of an immature phenotype, low cell yields and the need for extended culture for enhanced maturation. Although the intricate relationship between extracellular matrix (ECM) components and integrin expression levels plays a pivotal role during heart development, the impact of differentiation and maturation of cardiac cells on integrin behavior has not been thoroughly studied.
View Article and Find Full Text PDFAdvances in the Study of Pluripotent Stem Cells in Livestock.
Cell Prolif
February 2025
Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
Livestock pluripotent stem cells, derived either from early embryos or induced through somatic cell reprogramming technology, possess the unique ability to self-renew, maintain an undifferentiated state and differentiate into various cell types. Consequently, the generation of PSCs from agricultural animal species holds great potential for applications in livestock breed improvement, rapid propagation, disease modelling and xenotransplantation. However, compared to the great achievements made in mouse and human pluripotent stem cells research, the generation of livestock pluripotent stem cells still remains challenging.
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