Rationale And Objectives: This study aimed to create a radiomics nomogram using grayscale ultrasound (US) to predict human epidermal growth factor receptor 2 (HER-2) expression status preoperatively in invasive breast cancer (IBC) patients.
Materials And Methods: The study population was randomly divided into a training dataset (360 patients, 99 HER-2-positive) and a validation dataset (155 patients, 42 HER-2-positive). Clinical data, including US features, were collected. Radiomics features were extracted from grayscale US images, followed by feature selection to establish a radiomics score (Radscore) model. Univariate and multivariate logistic regression analyses identified independent risk factors for the clinical and radiomics nomogram models. Model performance was evaluated using receiver operating characteristic curves, calibration curves, decision curve analysis, net reclassification improvement, and integrated discrimination improvement.
Results: 16 radiomics features were selected for the Radscore model. Tumor margin and calcification emerged as significant preoperative risk factors for HER-2 status, forming the basis of a clinical prediction model. The integrated radiomics nomogram, combining tumor margin, calcification, and Radscore, demonstrated strong discrimination with area under the curve values of 0.810 in the training dataset and 0.807 in the validation dataset.
Conclusion: The US-based radiomics nomogram shows substantial promise for preoperatively predicting HER-2 status in IBC patients.
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| http://dx.doi.org/10.1016/j.acra.2024.12.059 | DOI Listing |
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