Introduction: Patient attitude to death is associated with outcomes in hospice care settings. This Korean study investigated the association between terminal cancer patient death acceptance and symptom control and quality of care (QoC) as perceived by family caregivers (FCs).
Methods: A multicenter cross-sectional survey was conducted in nine inpatient hospice care units, and the data of 108 dyads (terminal cancer patients who responded to the revised Death Attitude Profile and their primary FCs) were analyzed. Dyads were dichotomized into high and low groups by death-acceptance level. Multivariate regression models were used to examine the association between death acceptance and symptom severity/QoC as perceived by FCs.
Results: Patients in the high acceptance group were younger, educated to a higher level, more religious, and had better-functioning families. Patients with severe shortness of breath were less likely to accept the inevitability of death. FCs of patients with high acceptance of death were more satisfied with QoC, particularly in domains of individualized care and family relationships. In addition, the positive association between patient acceptance and FC satisfaction with care was significant in dyads of young or female patients, patients with a low education level, and patients not cared for by a spouse.
Conclusion: Terminal cancer patient death acceptance is associated with symptom control and FC perceived QoC.
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http://dx.doi.org/10.1177/10499091251318738 | DOI Listing |
Pain Manag Nurs
March 2025
University Center for Health Sciences, University of Guadalajara, Jalisco, México. Electronic address:
Purpose/objectives: Analyze the meaning of pain and suffering experienced by patients with end-stage cancer from a systemic perspective.
Design: Qualitative study based on General Systems Theory.
Sample/participants: Ten patients with terminal stage cancer were interviewed.
Background: This study aimed to investigate the assignment of" patient attendants"as outlined in the guidelines for home-based red blood cell transfusion therapy in Japan.
Methods: Among patients with cancer who received home-based treatment at our institution during the study period, 93 patients who underwent home-based red blood cell transfusion therapy and either died or were diagnosed in their terminal stage were included. Data were collected from medical records and analyzed retrospectively.
Gan To Kagaku Ryoho
February 2025
Dept. of Rehabilitation Medicine, Keio University School of Medicine.
As cancer becomes more of a chronic condition, cancer rehabilitation care aimed at maintaining and improving patients' quality of life(QOL)is becoming increasingly important. Cancer rehabilitation care addresses both disabilities caused by cancer itself and those that arise during the treatment process. Cancer rehabilitation is divided into four phases-preventive, restorative, supportive, and palliative.
View Article and Find Full Text PDFTalanta
March 2025
The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics, Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address:
The detection of glycosylation alterations is essential for elucidating the roles of glycan functions in biological processes and identifying potential disease biomarkers. Stable isotopic chemical labeling, coupled with mass spectrometry (MS), represents a powerful approach in quantitative glycomics. In this study, we synthesized a novel isotopic hydrazide pair, 2,6-Dimethyl-4-chinolincarbohydrazid (DMQCH) and its deuterium isomer DMQCH-d, via an efficient and cost-effective method, and applied it for the first time in MALDI-MS-based quantitative glycomics.
View Article and Find Full Text PDFPLoS One
March 2025
CENTD, Centre of Excellence in New Target Discovery, Instituto Butantan, São Paulo, Brazil.
The effective delivery of drugs remains a major challenge in the development of new therapeutic molecules. Several strategies have been employed to address this issue, with cell-penetrating peptides (CPPs) standing out due to their ability to traverse cell membranes with minimal cytotoxicity and their relatively straightforward synthesis when conjugated with other molecules. However, while CPPs can successfully enter the cytoplasm, they often lack specificity for particular organelles, leaving target engagement to the drug itself.
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