Methicillin-resistant (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn and vancomycin (Van) codelivered nanotherapeutic (named Man-Zn/Van NPs) was fabricated and characterized via mannose (Man) modification. Man-Zn/Van NPs exhibit significant inhibitory activity against extra- and intracellular MRSA and obviously decrease the minimum inhibitory concentration of Van. Man-Zn/Van NPs can be easily internalized by MRSA-infected macrophages and significantly accumulated in infected bone via Man-mediated targeting. In vivo experiments in a mouse OM model verified that Man-Zn/Van NPs significantly reduce the extra- and intracellular MRSA burden, improve gait patterns, increase bone mass, and decrease inflammatory cytokine expression. The antibacterial mechanism of Man-Zn/Van NPs includes destruction of the MRSA membrane, degeneration of intracellular proteins and DNA, inhibition of MRSA glycolysis, and intervention in the energy metabolism of bacteria. Overall, this metal-antibiotic nanotherapeutics strategy provides new insight for combating extra- and intracellular infections caused by MRSA-induced OM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsnano.4c11956 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Metal Ion and Antibiotic Co-loaded Nanoparticles for Combating Methicillin-Rresistant -Induced Osteomyelitis.
ACS Nano
January 2025
Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Methicillin-resistant (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn and vancomycin (Van) codelivered nanotherapeutic (named Man-Zn/Van NPs) was fabricated and characterized via mannose (Man) modification. Man-Zn/Van NPs exhibit significant inhibitory activity against extra- and intracellular MRSA and obviously decrease the minimum inhibitory concentration of Van.
View Article and Find Full Text PDFComparison of Hydrogen Bonded Organic Framework with Reduced Graphene Oxide-Pd Based Nanocatalyst: Which One Is More Efficient for Entrapment of Nitrophenol Pollutants?
Langmuir
January 2025
Prof. Rashidi Laboratory of Organometallic Chemistry & Material Chemistry, Department of Chemistry, College of Science, Shiraz University, Shiraz, 7194684795, Iran.
In this study, a Pd nanoparticles@hydrogen-bonded organic framework (Pd NPs@HOF) thin film was fabricated at the toluene-water interface. The HOF was formed through the interaction of trimesic acid (TMA) and melamine (Mel) in the water phase, while Pd(0) was produced from the reduction of [PdCl(cod)] in the organic phase. The as-synthesized Pd NPs@HOF thin film was demonstrated to be an effective catalyst for the selective reduction of -nitrophenol and -nitrophenol to -aminophenol and -aminophenol.
View Article and Find Full Text PDFTerbium-Labeled Gold Nanoparticles as Nanoscale Brachytherapy Agents Against Breast Cancer.
Materials (Basel)
January 2025
Radiochemical Studies Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research "Demokritos", Patriarchou Grigoriou and 27 Neapoleos Street, 15341 Athens, Greece.
Due to their intriguing emission profile, Terbium-161 (Tb) radiopharmaceuticals seem to bring significant advancement in theranostic applications to cancer treatment. The combination of Tb with nanoscale brachytherapy as an approach for cancer treatment is particularly advantageous and promising. Herein, we propose the application of a hybrid nanosystem comprising gold decorated (Au@TADOTAGA) iron oxide nanoflowers as a form of injectable nanobrachytherapy for the local treatment of breast cancer.
View Article and Find Full Text PDFDoxorubicin-Conjugated Nanoparticles for Potential Use as Drug Delivery Systems.
Nanomaterials (Basel)
January 2025
School of Sciences and Humanities, Nazarbayev University, Astana 010000, Kazakhstan.
Doxorubicin (DOX) is one of the most widely used chemotherapy drugs in the treatment of both solid and liquid tumors in patients of all age groups. However, it is likely to produce several side effects that include doxorubicin cardiomyopathy. Nanoparticles (NPs) can offer targeted delivery and release of the drug, potentially increasing treatment efficiency and alleviating side effects.
View Article and Find Full Text PDFAntibacterial activity of copper-decorated CeO nanoparticles and preparation of antifouling polyethersulfone surface.
Heliyon
December 2024
Department of Environmental Engineering, Faculty of Engineering, Mersin University, 33343, Yenisehir, Mersin, Turkey.
Cerium oxide NPs (-CeO), with notable performance in various biological tests like redox activity, free radical scavenging, and biofilm inhibition, emerge as significant candidates to address issues in related areas. In this research, copper-decorated -CeO (Cu@-CeO) were first synthesized and then characterized using advanced techniques such as SEM-EDX, XRD, XPS, BET, and ICP-OES. The biochemical properties of the obtained Cu@-CeO nanostructure and its performance in polyethersulfone (PES) membranes were thoroughly investigated in this research study.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!