Evaluation of the Effect of Topically Applied Melatonin and Vitamin C in the Non-surgical Treatment of Chronic Periodontitis: A Triple-Blind Randomized Clinical Trial.

Aim: This study aimed to evaluate the impact of using melatonin and vitamin C as adjuncts to the non-surgical treatment of chronic periodontitis.

Materials And Methods: This triple-blind randomized clinical trial involved 100 participants with chronic periodontitis. Subjects were randomly assigned to three groups: (1) non-surgical periodontal therapy (NSPT) alone (n = 33); (2) NSPT with melatonin (n = 33); and (3) NSPT with melatonin and vitamin C (n = 34). Clinical parameters, including gingival index (GI), probing depth (PD), and clinical attachment loss (CAL), were assessed at baseline and at one week, one month, and three months post treatment. Statistical significance was set at p ≤ 0.05.

Results: Compared to baseline, all groups showed significant improvements in periodontal parameters (p ≤ 0.001). At three months, the group receiving both melatonin and vitamin C demonstrated the greatest reduction in PD (mean reduction: 1.96 mm, p ≤ 0.001) and CAL (mean reduction: 1.87 mm, p ≤ 0.001). This group also achieved the most significant improvement in GI (mean reduction: 1.74, p ≤ 0.001).

Conclusions: The combined adjunctive therapy of melatonin and vitamin C demonstrated superior improvements in periodontal indices compared to NSPT alone, supporting its potential as an effective adjunctive treatment for chronic periodontitis.