The monkeypox (Mpox) virus has emerged as a global public health emergency of international concern recently. The virus that was endemic in West and Central Africa has now been reported with chains of global transmission to several countries. A scoping review was carried out from the relevant literature available from PubMed, Scopus and Web of Science. This comprehensive analysis describes the virus epidemiology, pathogenesis, clinical manifestations, complications including secondary bacterial infections, diagnosis, treatment and vaccination. The article underscores the significance of key viral and immune mediators of infection and discusses updated recommendations on therapeutic strategies and vaccination.
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http://dx.doi.org/10.1155/cjid/6683501 | DOI Listing |
Cureus
December 2024
Radiology Department, Universidad Internacional del Ecuador, Quito, ECU.
Monkeypox (Mpox) was declared a public health emergency in 2022. The most common form of presentation is a self-limited illness associated with a skin rash. However, immunocompromised patients may present with more severe forms of the disease.
View Article and Find Full Text PDFFront Chem
January 2025
NanoStruc Research Group, Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt.
Background: Monkeypox (Mpox) is a re-emerging zoonotic disease with limited therapeutic options, necessitating the exploration of novel antiviral agents. (turmeric) is a widely used medicinal plant known for its antioxidant and anti-inflammatory properties, primarily attributed to its bioactive curcuminoids.
Aim: This study aimed to evaluate the therapeutic potential of aqueous extract (CAE) against monkeypox through phytochemical characterization, biological assays, and computational analyses.
Can J Infect Dis Med Microbiol
January 2025
Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Linköping University, Linköping 58183, Sweden.
The monkeypox (Mpox) virus has emerged as a global public health emergency of international concern recently. The virus that was endemic in West and Central Africa has now been reported with chains of global transmission to several countries. A scoping review was carried out from the relevant literature available from PubMed, Scopus and Web of Science.
View Article and Find Full Text PDFSci Rep
January 2025
Electronics and Communication Engineering Department, Mansoura University, Mansoura, 35516, Egypt.
As the world recovered from the coronavirus, the emergence of the monkeypox virus signaled a potential new pandemic, highlighting the need for faster and more efficient diagnostic methods. This study introduces a hybrid architecture for automatic monkeypox diagnosis by leveraging a modified grey wolf optimization model for effective feature selection and weighting. Additionally, the system uses an ensemble of classifiers, incorporating confusion based voting scheme to combine salient data features.
View Article and Find Full Text PDFNat Commun
January 2025
CAS Key Laboratory of Urban Pollutant Conversion, Department of Environmental Science and Engineering, University of Science and Technology of China, 230026, Hefei, China.
The CRISPR-based detection methods have been widely applied, yet they remain limited by the non-universal nature of one-pot diagnostic approaches. Here, we report a universal one-pot fluorescent method for the detection of epidemic pathogens, delivering results within 15-20 min. This method uses heparin sodium to precisely tunes the cis-cleavage capability of Cas12 via interference with the Cas12a-crRNA binding process, thereby generating significant fluorescence due to the accumulation of isothermal amplification products.
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