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Artesunate: attenuating TLR4/MD2 signaling to alleviate cardiac fibrosis.
Signal Transduct Target Ther
January 2025
Department of Medicine 2, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Artesunate alleviates radiation-induced submandibular gland epithelial cell damage in rats by reducing inflammation and apoptosis.
Cell Biol Int
November 2024
College & Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China.
Salivary hypofunction is a common complication in patients with head and neck cancers following radiotherapy (RT). RT-induced inflammation in salivary gland cells leads to apoptosis and fibrosis. Artesunate (ART) is a bioactive compound with anti-inflammatory and anti-fibrosis properties.
View Article and Find Full Text PDFMultiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target.
Cell
December 2024
Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:
Cardiac fibrosis impairs cardiac function, but no effective clinical therapies exist. To address this unmet need, we employed a high-throughput screening for antifibrotic compounds using human induced pluripotent stem cell (iPSC)-derived cardiac fibroblasts (CFs). Counter-screening of the initial candidates using iPSC-derived cardiomyocytes and iPSC-derived endothelial cells excluded hits with cardiotoxicity.
View Article and Find Full Text PDFThe antimalarial profiling of 's herbal formulation attenuated biochemical alterations and improved hepatocytes' histoarchitecture in -infected mice.
J Parasit Dis
June 2024
Department of Biochemistry, Arthur Jarvis University, Akpabuyo, Cross River State Nigeria.
Plasmodium parasite causes malaria and affects the biochemical, physiological, and histoarchitecture of the hepatocytes and blood. The resultant effect leads to alterations in the metabolic activities of the liver, erythrocytes, as well as the buffer system. Therefore, we investigated the antiplasmodial activity, histomorphological studies of the hepatocytes and alterations in biochemical parameters in infected mice administered with the herbal formulation of aqueous extracts of stem bark and leaves.
View Article and Find Full Text PDFCorrigendum to "Artesunate ameliorates ligature-induced periodontitis by attenuating NLRP3 inflammasome-mediated osteoclastogenesis and enhancing osteogenic differentiation" [Int. Immunopharmacol. 123 (2023) 110749].
Int Immunopharmacol
December 2024
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:
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