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Ripple Effects of Early Life Stress on Vascular Health.

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January 2025

Cardio-Renal Physiology and Medicine, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, AL (C.E.K., G.C.K., J.S.P.).

The term early life stress encompasses traumatic events occurring before the age of 18 years, such as physical abuse, verbal abuse, household dysfunctions, sexual abuse, childhood neglect, child maltreatment, and adverse childhood experiences. Adverse psychological experiences in early life are linked to enduring effects on mental and physical health in adulthood. In this review, we first describe the effects and potential mechanisms of early life stress on the components of the vasculature.

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Identifying proximal and multigenerational distal risk mechanisms through which adversity exposure may shape neuroendocrine dysregulation among children is critical to advancing effective preventive interventions for adversity-exposed individuals. Utilizing longitudinal data ( = 247), the current study examined maternal and offspring history of childhood maltreatment (CM) as predictors of offspring cortisol/DHEA ratios, and, in exploratory analyses, extended this longitudinally to offspring depressive symptoms in young adulthood. Youth (ages 8-13 years) initially attended a research camp, then were followed up approximately eight years later (ages 18-22 years).

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Importance: Childhood maltreatment (CM) is associated with the early onset of psychiatric and medical disorders and accelerated biological aging.

Objective: To identify types of maltreatment and developmental sensitive periods that are associated with accelerated adult brain aging.

Design: Participants were mothers of infants recruited from the community into a study assessing the effects of CM on maternal behavior, infant attachment, and maternal and infant neurobiology.

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The effects of unconditional cash transfers on child abuse and neglect in early childhood: Evidence from New Zealand.

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January 2025

Centre of Methods and Policy Applications in the Social Sciences (COMPASS), The School of Social Sciences, University of Auckland, 1010, New Zealand.

Background: Child abuse and neglect is recorded at higher rates in families with low incomes, and in contexts with lower public spending on families. However, it is not clear whether modest cash transfers could reduce rates.

Objective: To estimate the effects of unconditional cash transfers to mothers with children under 3 years of age on child abuse and neglect.

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