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Eur Respir J
January 2025
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders.
Am J Psychiatry
January 2025
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY (Stern, Collins, Bragdon, Eng, Recchia, Tobe, Iosifescu); Department of Psychiatry (Stern, Bragdon, Eng, Recchia, Iosifescu) and Neuroscience Institute (Stern, Iosifescu), New York University Langone Medical Center, New York; Department of Psychiatry, University of Miami Medical School, Miami (Coffey); Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Leibu, Murrough); Center for the Developing Brain, Child Mind Institute, New York (Tobe); Department of Psychiatry, Brigham and Women's Hospital, Boston (Burdick); Harvard Medical School, Boston (Burdick); Department of Psychiatry, Baylor College of Medicine, Houston (Goodman).
Objective: Sensory phenomena (SP) are aversive sensations driving repetitive behaviors in obsessive-compulsive disorder (OCD) and Tourette's disorder that are not well addressed by standard treatments. SP are related to the functioning of an interoceptive-sensorimotor circuit that may be modulated by the 5-HT receptor antagonist ondansetron. The present study employed an experimental medicine approach to test the effects of 4 weeks of high-dose ondansetron compared to placebo on SP severity and brain connectivity in a cohort of individuals with OCD and/or Tourette's disorder.
View Article and Find Full Text PDFDriving Innovation to Support Pupils with SEND Through Co-Production in Education and Research: Participatory Action Research with 22q11.2 Deletion Syndrome Families in England.
Behav Sci (Basel)
December 2024
School of Psychology, University of Roehampton, London SW15 4JD, UK.
Children and young people (CYP) with special educational needs and disabilities (SEND) comprise over 1.6 million pupils in classrooms in England. However, evidence suggests pupils' learning and wellbeing needs are often missed or unmet and legislation designed to increase families' decision-making in education provision has not been translated into practice.
View Article and Find Full Text PDFGrowth-tolerance tradeoffs shape the survival outcomes and ecophysiological strategies of Atlantic Forest species in the rehabilitation of mining-impacted sites.
Sci Total Environ
January 2025
Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais 31270-901, Brazil. Electronic address:
The initial performance of seedlings of tree species from different functional groups, regarding the growth-defense tradeoff, might determine its long-term success during the rehabilitation of mining areas. We monitored the field performance of six native tree species of the Atlantic Forest in the Fundão dam tailing that has been under rehabilitation for 35 months. Additionally, we explored the morphophysiological traits driving the superior performance of three species.
View Article and Find Full Text PDFFriedreich Ataxia: An (Almost) 30-Year History After Gene Discovery.
Neurol Genet
February 2025
Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
In the late 1800s, Nikolaus Friedreich first described "degenerative atrophy of the posterior columns of the spinal cord," noting its connection to progressive ataxia, sensory loss, and muscle weakness, now recognized as Friedreich ataxia (FRDA). Renewed interest in the disease in the 1970s and 80s by the Quebec Cooperative Group and by Anita Harding led to the development of clinical diagnostic criteria and insights into associated biochemical abnormalities, although the primary defect remained unknown. In 1988, Susan Chamberlain mapped FRDA's location on chromosome 9.
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