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Intra-aortic entrainment pump for LV unloading: What phase of the cardiac cycle does the device unload?
J Card Fail
January 2025
Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai. Electronic address:
Left Ventricular Unloading Using Intra-aortic Entrainment Pumping Before Reperfusion Reduces Post-AMI Infarct Size.
J Card Fail
August 2024
Duke University Medical Center, Durham, North Carolina.
Article Synopsis
- Recent studies suggest that unloading the left ventricle (LV) for 30 minutes before coronary reperfusion during anterior myocardial infarction can reduce the size of the infarct after 28 days.
- An experiment using Yorkshire swine found that those who received this unloading treatment prior to reperfusion had significantly better cardiac function and a 37%-45% reduction in LV scar size compared to those who underwent immediate reperfusion.
- These findings indicate that extracardiac LV unloading using intra-aortic pumping could be a promising approach to improve outcomes after a heart attack.
A Mock Circulatory Loop Analysis of Cardiorenal Hemodynamics With Intra-Aortic Mechanical Circulatory Support.
ASAIO J
February 2025
From the Department of Cardiology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia.
Type 1 cardiorenal syndrome is associated with significant excess morbidity and mortality in patients with severe acute decompensated heart failure. Previous trials of vasoactive drugs and ultrafiltration have not shown superiority over placebo or intravenous diuretics. Pilot data suggest short-term mechanical support devices may support diuresis in the cardiorenal syndrome.
View Article and Find Full Text PDFSafety and Performance of the Aortix Device in Acute Decompensated Heart Failure and Cardiorenal Syndrome.
JACC Heart Fail
November 2023
Inova Heart and Vascular Institute, Falls Church, Virginia, USA. Electronic address:
Background: Cardiorenal syndrome (CRS) complicates 33% of acute decompensated heart failure (ADHF) admissions, and patients with persistent congestion at discharge have high 30-day event rates.
Objectives: The purpose of this study was to evaluate a novel catheter-deployed intra-aortic entrainment pump (IAEP) in patients with ADHF with CRS and persistent congestion.
Methods: A multicenter (n = 14), nonrandomized, single-arm, safety and feasibility study of IAEP therapy was conducted.
Future Devices for Percutaneous Mechanical Circulatory Support.
Interv Cardiol Clin
April 2021
Section of Cardiology, Advanced Heart Failure, University of Chicago Medicine, 5841 South Maryland Avenue, Room A621-MC2016, Chicago, IL 60637, USA.
Percutaneous mechanical circulatory support options include intra-aortic balloon pump, transvalvular axial flow pumps, left atrial to femoral artery pumping, and oxygenated right atrium to femoral artery circuits. Percutaneous mechanical circulatory support devices providing greater support have not proven superiority over the intra-aortic balloon pump. Novel counterpulsation devices target durability and ambulatory capability and direct unloading of left ventricle (LV) and right ventricle.
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