Probiotics have brought many health benefits to the human body. However, their viability during gastrointestinal transit is a concern. Therefore, this study selected Mesona chinensis polysaccharide (MCP), an edible natural polysaccharide, and constructed a new type of microcapsules using MCP as raw material to prepare cross-linked calcium ions through a microfluidic system as an ideal intestinal targeting carrier to achieve precise delivery of bioactive substances. The results showed that the Mesona chinensis polysaccharide microcapsules (MCM) had high monodispersity, stable morphology and uniform particle size (737.25 ± 10.40-511.65 ± 10.99 μm) under various parameters, and had good pH-response ability in simulated body fluids. In vivo imaging demonstrated the targeting and protective effects of the microcapsules. Compared to the free group, MCM had a longer retention time in the intestine. After encapsulating Lactobacillus plantarum, MCM formed a dense protective layer on the outer layer in simulated gastric fluid, which improved the survival and storage stability of Lactobacillus plantarum. It can be reasonably proposed that MCM represents a viable alternative as a carrier with gastric acid protection and intestinal targeting. This has the potential to expand the application of MCP in functional food and medicine, while also facilitating the future delivery of bioactive substances.
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