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Unveiling the Fourth Dimension: Strain Analysis with Computed Tomography Scans in Transcatheter Aortic Valve Replacement Innovation.
Can J Cardiol
January 2025
Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Canada; Division of Cardiology, Terrence Donnelly Heart Centre, St Michael's Hospital, 30 Bond Street, Toronto, Canada; Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.
The hypothalamus as the central regulator of energy balance and its impact on current and future obesity treatments.
Arch Endocrinol Metab
January 2025
Universidade de Campinas Centro de Pesquisa em Obesidade e Comorbidades CampinasSP Brasil Centro de Pesquisa em Obesidade e Comorbidades, Universidade de Campinas, Campinas, SP, Brasil.
The hypothalamus is a master regulator of energy balance in the body. First-order hypothalamic neurons localized in the arcuate nucleus sense systemic signals that indicate the energy stores in the body. Through distinct projections, arcuate nucleus neurons communicate with second-order neurons, which are mostly localized in the paraventricular nucleus and in the lateral hypothalamus.
View Article and Find Full Text PDFUnmasking the Dark Triad: A Data Fusion Machine Learning Approach to Characterize the Neural Bases of Narcissistic, Machiavellian and Psychopathic Traits.
Eur J Neurosci
January 2025
Department of Psychology and Cognitive Sciences (DiPSCo), University of Trento, Trento, Italy.
The Dark Triad (DT), encompassing narcissism, Machiavellianism and psychopathy traits, poses significant societal challenges. Understanding the neural underpinnings of these traits is crucial for developing effective interventions and preventive strategies. Our study aimed to unveil the neural substrates of the DT by examining brain scans from 201 individuals (mean age: 32.
View Article and Find Full Text PDFUnveiling the Immune Landscape of Delirium through Single-Cell RNA Sequencing and Machine Learning: Towards Precision Diagnosis and Therapy.
Psychogeriatrics
January 2025
Department of Anesthesiology, The Fourth Hospital of Shijiazhuang, Shijiazhuang, China.
Background: Postoperative delirium (POD) poses significant clinical challenges regarding its diagnosis and treatment. Identifying biomarkers that can predict and diagnose POD is crucial for improving patient outcomes.
Methods: To explore potential biomarkers for POD, we conducted bulk RNA sequencing (bulk-seq) on peripheral blood samples from POD patients and healthy controls.
Dual PTCH2 mutation [Ser391*, Leu104Pro]: unveiling a potential new genetic susceptibility factor for glioma development.
Invest New Drugs
January 2025
Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453100, Henan, China.
Gliomas are a heterogeneous type of central nervous system tumor. The etiology of glioma formation remains elusive, with approximately 5% of gliomas being familial, underscoring the significance of understanding genetic susceptibility in glioma development. In this study, a dual germline PTCH2 mutation [Ser391*, Leu104Pro] was identified in a family with a history of glioma, and sequencing data from WES/SimcereDx Neuro-Onco 360 including 910 Chinese patients with glioma and 1666 patients with solid tumors were analyzed.
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