Although smart contact lenses have demonstrated great potential in theranostics, there remain critical challenges and opportunities in their commercial development. In this Perspective, the current status and capability of smart theranostic contact lenses are highlighted, focusing on their application as sensing systems for detecting biomarkers such as glucose, intraocular pressure (IOP), and inflammatory cytokines, and as drug delivery systems (DDS) for precise and controlled therapy. Additionally, key challenges associated with clinical development and commercialization of smart theranostic contact lenses are discussed, to optimize diagnostic and therapeutic interventions. Considering the rapid evolution of the field, we finally also discuss the need for systematic studies on safety, efficacy, and mass-production, and we spark new ideas for advancing smart theranostic contact lenses into versatile platforms for personalized medicine.
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| http://dx.doi.org/10.1016/j.jconrel.2025.01.082 | DOI Listing |
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Background: Orthokeratology (OK) contact lenses are increasingly prescribed for myopia control but their impact on corneal epithelial immune cells (CEIC) is unclear. This study compares CEIC in OK wearers to soft contact lens (SCL) wearers and non-wearers.
Methods: In vivo confocal microscope images at the corneal central and mid-peripheral subbasal level were evaluated in 18 OK wearers, 18 SCL wearers and 18 non-wearers (mean age 27.
Smart theranostic contact lenses.
J Control Release
January 2025
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Republic of Korea. Electronic address:
Although smart contact lenses have demonstrated great potential in theranostics, there remain critical challenges and opportunities in their commercial development. In this Perspective, the current status and capability of smart theranostic contact lenses are highlighted, focusing on their application as sensing systems for detecting biomarkers such as glucose, intraocular pressure (IOP), and inflammatory cytokines, and as drug delivery systems (DDS) for precise and controlled therapy. Additionally, key challenges associated with clinical development and commercialization of smart theranostic contact lenses are discussed, to optimize diagnostic and therapeutic interventions.
View Article and Find Full Text PDFSelf-reported prevalence and risk factors associated with keratoconus among the adult population of Trinidad and Tobago: a cross-sectional study.
Int Ophthalmol
January 2025
Discipline of Optometry, University of KwaZulu-Natal, Durban, South Africa.
Aim: To determine the prevalence of keratoconus and its associated risk factors within the adult population of Trinidad and Tobago.
Method: A population-based cross-sectional study was conducted among adults in Trinidad and Tobago, utilizing the Keratoconus Risk Assessment Questionnaire (KRIS) for data collection. Data were exported to the Statistical Package for Social Sciences (SPSS) version 27 for analysis.
Intracameral voriconazole for severe fungal keratitis: a case series.
Arq Bras Oftalmol
January 2025
Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Purpose: This study aimed to report the use, efficacy, and safety of intracameral voriconazole as an adjuvant treatment for deep fungal keratitis.
Methods: This was a prospective case series of seven eyes with fungal keratitis with anterior chamber involvement or a corneal ulcer refractory to conventional topical treatment. In addition to topical treatment with 0.
Analysis and optimization of the landing zone parameters of a sclera lens model.
Arq Bras Oftalmol
January 2025
Ophthalmology and Visual Sciences Department, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Purpose: This study aimed to modify scleral contact lenses to achieve a desired compression standard and to evaluate the effectiveness and reliability of the adjustments.
Methods: In this nonrandomized, noncomparative, and partially masked study Scleral contact lens fittings were analyzed in 20 eyes of 12 patients (50% women, 50% men) diagnosed with keratoconus. Participants were selected based on their need for scleral contact lenses (SCLs), which was determined in complete ophthalmological examinations.
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