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Multiomics unravels the complexity of male obesity: a prospective observational study.
J Transl Med
January 2025
Department of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Background: Obesity is associated with varying degrees of metabolic dysfunction. In this study, we aimed to discover markers of the severity of metabolic impairment in men with obesity via a multiomics approach.
Methods: Thirty-two morbidly men with obesity who were candidates for Roux-en-Y gastric bypass (RYGB) surgery were prospectively followed.
Unraveling the Complexities of ECPR Outcomes in Infants with Single Ventricle Physiology.
Resuscitation
January 2025
Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ASGCL: Adaptive Sparse Mapping-based graph contrastive learning network for cancer drug response prediction.
PLoS Comput Biol
January 2025
School of Software, Taiyuan University of Technology, Taiyuan, China.
Personalized cancer drug treatment is emerging as a frontier issue in modern medical research. Considering the genomic differences among cancer patients, determining the most effective drug treatment plan is a complex and crucial task. In response to these challenges, this study introduces the Adaptive Sparse Graph Contrastive Learning Network (ASGCL), an innovative approach to unraveling latent interactions in the complex context of cancer cell lines and drugs.
View Article and Find Full Text PDFDecoding the genetic blueprint: regulation of key agricultural traits in sorghum.
Adv Biotechnol (Singap)
September 2024
School of Agriculture and Biotechnology, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Sorghum, the fifth most important crop globally, thrives in challenging environments such as arid, saline-alkaline, and infertile regions. This remarkable crop, one of the earliest crops domesticated by humans, offers high biomass and stress-specific properties that render it suitable for a variety of uses including food, feed, bioenergy, and biomaterials. What's truly exciting is the extensive phenotypic variation in sorghum, particularly in traits related to growth, development, and stress resistance.
View Article and Find Full Text PDFMicroplastic pollution in aquatic ecosystems: impacts on diatom communities.
Environ Monit Assess
January 2025
Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.
In recent years, heightened concern has emerged regarding the pervasive presence of microplastics in the environment, particularly in aquatic ecosystems. This concern has prompted extensive scientific inquiry into microplastics' ecological and physiological implications, including threats to biodiversity. The robust adsorption capacity of microplastic surfaces facilitates their widespread distribution throughout aquatic ecosystems, acting also as carriers of organic pollutants.
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