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Universal Karyotyping for Oocyte Donors: Necessary Safeguard or Unnecessary Expense?
Fertil Steril
January 2025
Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address:
Frequent variations and phylogenetic relationships within the genus identified by ND-FISH according to the genome-wide universal oligonucleotides chromosome probes.
Front Plant Sci
December 2024
State key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, China.
Introduction: Rye ( L.) played a very important role in wheat genetic improvement and forage production worldwide. However, since rye is a kind of cross-pollinated plant, high levels of genetic heterozygosity and heterogeneity existed in the genome.
View Article and Find Full Text PDFPreimplantation genetic testing for structural rearrangements by genome-wide SNP genotyping and haplotype analysis: a prospective multicenter clinical study.
EBioMedicine
January 2025
Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250012, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China; Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200135, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200135, China. Electronic address:
Background: Preimplantation genetic testing for chromosomal structural rearrangements (PGT-SR) has been widely utilized to select euploid embryos in patients carrying balanced chromosomal rearrangements (BCRs) by chromosome copy number analysis. However, reliable and extensively validated PGT-SR methods for selecting embryos without BCRs in large-cohort studies are lacking.
Methods: In this prospective, multicenter, cohort study, carriers with BCRs undergoing PGT-SR were recruited across 12 academic fertility centers within China.
Accurate vector copy number determination in gammaretroviral vector producer cell clones using triplex digital droplet PCR.
J Virol Methods
February 2025
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan; Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address:
Gammaretroviral vectors are widely used in cellular and gene therapy products because of the availability of stable vector producer cells. Accurately assessing vector copy number (VCN) is critical for selecting appropriate clones to avoid the risks of homologous recombination and complications in mutation detection. Traditional methods such as quantitative polymerase chain reaction (PCR) and Southern blotting have limitations in accuracy and throughput.
View Article and Find Full Text PDFChromosome-scale genome assembly of and comparative genomic analyses shed light on its genome evolution.
Front Plant Sci
November 2024
Yunnan Provincial Key Laboratory of Biological Big Data, Yunnan Agricultural University, Kunming, Yunnan, China.
Article Synopsis
- - This study presents the first comprehensive genome assembly of a significant plant in traditional Chinese medicine, revealing its edible and medicinal traits while addressing the lack of genomic resources.
- - The genome assembly is high-quality at 679.20 Mb, anchored to 8 pseudo-chromosomes with a 96.5% anchoring rate and demonstrates high completeness at 97.6%, indicating a well-structured genomic framework.
- - The research highlights the evolutionary history of the plant, including its polyploidization and gene family expansions, providing critical insights for conservation and sustainable utilization of the species.
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