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Countering antimicrobial resistance.
Pulmonology
December 2025
Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
Cdr1 in focus: a personal reflection on multidrug transporter research.
FEMS Yeast Res
January 2025
Amity Institute of Integrative Science and Health, Amity University Haryana, Gurugram, 122413, India.
Drug resistance mechanisms in human pathogenic Candida species are constantly evolving. Over time, these species have developed diverse strategies to counter the effects of various drug classes, making them a significant threat to human health. In addition to well-known mechanisms such as drug target modification, overexpression, and chromosome duplication, Candida species have also developed permeability barriers to antifungal drugs through reduced drug import or increased efflux.
View Article and Find Full Text PDFAntifungal activity of 2-adamantylamine hydrochloride on and .
J Med Microbiol
January 2025
Department of Stem Cell and Regenerative Medicine, Medical Biotechnology, Centre for Interdisciplinary Research, D.Y. Patil Education Society (Deemed to be University), Kolhapur- 416-003, Maharashtra, India.
Increased virulence and drug resistance in species of resulted in reduced disease control and further demand the development of potent antifungal drugs. The repurposing of non-antifungal drugs and combination therapy has become an attractive alternative to counter the emerging drug resistance and toxicity of existing antifungal drugs against and non-albicans species. This study aimed to accelerate antifungal drug development process by drug repurposing approach.
View Article and Find Full Text PDFManagement factors affecting milk yield, composition, and quality on smallholder dairy farms.
Trop Anim Health Prod
January 2025
Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7024, 750 07, Uppsala, Sweden.
A cross-sectional study on 156 smallholder dairy farms in Rwanda was carried out to assess the association between farm management practices and milk yield and quality. A pre-tested questionnaire was used to collect data on cow characteristics and farm management practices. Milk yield was recorded at household level, milk composition was monitored using a Lactoscan device (Milk Analyzer).
View Article and Find Full Text PDFPotentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes.
Technol Cancer Res Treat
January 2025
Cell Therapy Center, The University of Jordan, Amman, Jordan.
Background: Doxorubicin (DOX) is a potent chemotherapeutic agent for breast cancer, but its effectiveness is often diminished by resistance mechanisms, particularly through p-glycoprotein (P-gp) mediated drug efflux. Clarithromycin (CAM), a macrolide antibiotic, inhibits multiple metabolic pathways including CYP3A and P-gp, potentially countering DOX resistance.
Objective: This study aimed to evaluate the potentiation of DOX and its effectiveness against the MCF-7 breast cancer cell line by encapsulating both DOX and CAM in PEGylated liposomes.
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