Due to the association with the causal human papillomavirus 16 (HPV16) infection, oropharyngeal squamous cell carcinoma is now separated into two distinct entities depending on HPV16 positivity. More recent data show a diversified picture of the importance and prevalence of the surrogate parameter p16 (discordance) for a definitive HPV16 association, which varies worldwide. In the context of preventive options, vaccination is of major importance and HPV screening of healthy people of less importance. The current CME article excerpts parts of the new German S3 guideline on diagnosis, treatment, prevention, and aftercare of oro- and hypopharyngeal cancer (version 1.0, March 2024; Association of the Scientific Medical Societies in Germany [AWMF] registration number 017-082OL).
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| http://dx.doi.org/10.1007/s00106-025-01552-0 | DOI Listing |
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