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Redirecting Research to Alzheimer's Disease.
Cent Nerv Syst Agents Med Chem
January 2025
International Center of Neuroscience and Genomic Medicine, EuroEspes Biomedical Research Center, Corunna, Spain.
Witnessing Self-Affirming Moments in Persons with Dementia While Interacting with Therapy Dogs: A Case Report.
Animals (Basel)
December 2024
Department of Sociology, University of Saskatchewan, Saskatoon, SK S4N 5A5, Canada.
Individuals, families, and communities are impacted by Alzheimer's disease and other dementias worldwide. In Canada and elsewhere, family members commonly see loved ones living with dementia experience difficult moments, including anxiety, stress, and fear. Struggling health care systems strive to apply the latest evidence-based interventions.
View Article and Find Full Text PDFEfficient Seeding of Cerebral Vascular Aβ-Amyloidosis by Recombinant AβM1-42 Amyloid Fibrils.
J Mol Biol
February 2025
Department of Physics, Chemistry and Biology (IFM), Linköping University, 581 83 Linköping, Sweden. Electronic address:
Aβ-amyloid plaques and cerebral amyloid angiopathy (CAA) in the brain are pathological hallmarks of Alzheimer's disease (AD) and vascular dementia. The spreading of Aβ amyloidosis in the brain appears to be mediated by a seeding mechanism, where preformed fibrils (called seeds) accelerate Aβ fibril formation by bypassing the rate-determining nucleation step. Several studies have demonstrated that Aβ amyloidosis can be induced in transgenic mice, producing human Aβ, by injecting Aβ-rich brain extracts (seeds) derived from transgenic mice and human AD brains.
View Article and Find Full Text PDFDeep learning-based patient stratification for prognostic enrichment of clinical dementia trials.
Brain Commun
December 2024
Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin 53757, Germany.
Dementia probably due to Alzheimer's disease is a progressive condition that manifests in cognitive decline and impairs patients' daily life. Affected patients show great heterogeneity in their symptomatic progression, which hampers the identification of efficacious treatments in clinical trials. Using artificial intelligence approaches to enable clinical enrichment trials serves a promising avenue to identify treatments.
View Article and Find Full Text PDFInput of exome sequencing in early-onset cerebral amyloid angiopathy.
Alzheimers Dement (Amst)
November 2024
Department of Neurology and CNRMAJ Univ Rouen Normandie Rouen France.
Article Synopsis
- The study explores the genetics of cerebral amyloid angiopathy (CAA), which is not widely researched and can impact the understanding of Alzheimer's disease (AD).
- Researchers conducted exome sequencing on 78 patients diagnosed with early-onset CAA, finding notable genetic variants, including pathogenic NOTCH3 mutations in two patients related to CADASIL, a rare vascular condition.
- The findings suggest that there are shared genetic factors between AD and CAA beyond just the APOE gene, with potential susceptibility linked to other rare genetic variants in various risk factor genes.
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