Background: Intrahepatic cholangiocarcinoma (ICC) presents a significant clinical challenge due to its high fatality rate and limited surgical candidacy. With only 30-40% of patients eligible for surgery upon diagnosis, alternative therapies are imperative. This study assesses the efficacy of Yttrium-90 (Y-90) radioembolization for unresectable ICC patients in a non-university tertiary care center (NUTCC).
Methods: A retrospective analysis of 15 unresectable ICC patients treated with Y-90 radioembolization was conducted. Tumor response, survival, and adverse events were evaluated using RECIST criteria.
Results: 60% of patients exhibited partial response, and 20% showed stable disease, with notable tumor size reduction and a median survival of 14 months. Minimal adverse effects were observed, indicating Y-90's favorable safety profile.
Conclusion: Y-90 radioembolization shows potential in reducing tumor burden and enhancing survival rates with minimal adverse effects for unresectable ICC. Larger prospective studies are needed to confirm its efficacy and define its role in ICC treatment protocols.
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Background: Intrahepatic cholangiocarcinoma (ICC) presents a significant clinical challenge due to its high fatality rate and limited surgical candidacy. With only 30-40% of patients eligible for surgery upon diagnosis, alternative therapies are imperative. This study assesses the efficacy of Yttrium-90 (Y-90) radioembolization for unresectable ICC patients in a non-university tertiary care center (NUTCC).
View Article and Find Full Text PDFPrediction of left lobe hypertrophy with voxel-based dosimetry using integrated Y-90 PET/MRI after radioembolization of liver tumors with Y-90 microspheres.
Eur J Nucl Med Mol Imaging
December 2024
Ankara University Medical School Department of Nuclear Medicine, Ankara, Turkey.
Purpose: The aim of this study was to investigate the relationship between voxel-based dosimetric variables derived from Y-90 PET/MRI and hypertrophy observed in the left lobe after radioembolization and to investigate if there is any difference in hypertrophy induced by glass versus resin microspheres.
Methods: Voxel-based dosimetry-derived variables and their relationship with the change of the standardized future liver remnant (ΔFLR) was investigated with linear regression models. To compare and evaluate the discriminatory power of the dosimetric variables, ROC analyses were utilized.
A 78-Year-Old Man With Shortness of Breath After Radioembolization of the Liver.
Chest
October 2024
Department of Medicine, King Faisal Specialist Hospital and Research Centre, Madinah, Saudi Arabia. Electronic address:
Article Synopsis
- * His GIST was initially diagnosed 10 years prior, leading to surgery, but recent biopsies confirmed liver metastases.
- * He had pre-existing heart conditions but no lung issues before the radioembolization treatment with Y-90 microspheres, which he underwent after starting imatinib therapy.
Assessment of Y-90 Radioembolization Treatment Response for Hepatocellular Carcinoma Cases Using MRI Radiomics.
Mol Imaging Radionucl Ther
October 2024
Taipei Veterans General Hospital, Clinic of Radiology, Taipei, Taiwan.
Objectives: This study aimed to investigate the ability of radiomics features extracted from magnetic resonance imaging (MRI) images to differentiate between responders and non-responders for hepatocellular carcinoma (HCC) cases who received Y-90 transarterial radioembolization treatment.
Methods: Thirty-six cases of HCC who underwent MRI scans after Y-90 radioembolization were included in this study. Tumors were segmented from MRI T2 images, and then 87 radiomic features were extracted through the LIFEx package software.
Voxel-based dosimetry with integrated Y-90 PET/MRI and prediction of response of primary and metastatic liver tumors to radioembolization with Y-90 glass microspheres.
Ann Nucl Med
January 2025
Department of Nuclear Medicine, Ankara University Medical School, Ankara, Turkey.
Purpose: In this study, we aimed to evaluate the response of the primary and metastatic liver tumors to radioembolization with Y glass microspheres and investigate its correlations with dosimetric variables calculated with Y PET/MRI.
Methods: In this ambispective study, 44 patients treated with Y glass microspheres and imaged with Y PET/MRI were included for analysis. Dosimetric analysis was performed for every perfused lesion using dose-volume histograms.
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